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用噻康唑(癣敌)治疗皮肤真菌感染

[Treatment of fungus infections of the skin with tioconazole (Mykontral)].

作者信息

Haustein U F, Seebacher C, Taube K M

出版信息

Dermatol Monatsschr. 1989;175(12):751-6.

PMID:2693142
Abstract

73 patients with fungal infections due to dermatophytes (49), yeasts (16) and Malassezia furfur (8) could be cured clinically in 71% and mycologically in 88% of cases by the application of Mycontral-Lotion or -cream twice daily for 33 days on average. In 28% improvement could be reached, in one patient the therapy failed. Treatment is simple, clean and well acceptable. Side-effects occurred as slight redness, transient burning and pruritus on the eroded skin in the initial phase in 8 patients (11%). Mykontral contains 1% tioconazole as a modern imidazol compound. It has been characterized as an effective topical broad spectrum antimycotic agent. Its introduction and application in the GDR is to be recommended.

摘要

73例由皮肤癣菌(49例)、酵母菌(16例)和糠秕马拉色菌(8例)引起真菌感染的患者,平均每天外用Mycontral洗液或乳膏两次,持续33天,临床治愈率达71%,真菌学治愈率达88%。28%的患者病情有所改善,1例患者治疗失败。该治疗方法简单、清洁且易于接受。8例患者(11%)在初始阶段出现轻微发红、短暂烧灼感和糜烂皮肤瘙痒等副作用。Mykontral含有1%的噻康唑,这是一种新型咪唑类化合物。它被认为是一种有效的外用广谱抗真菌剂。推荐在民主德国引入和应用该药物。

相似文献

1
[Treatment of fungus infections of the skin with tioconazole (Mykontral)].用噻康唑(癣敌)治疗皮肤真菌感染
Dermatol Monatsschr. 1989;175(12):751-6.
2
[1% tioconazole powder in the treatment of dermatomycoses].1% 噻康唑粉剂治疗皮肤真菌病
Clin Ter. 1988 Sep 30;126(6):417-20.
3
Topical treatment of dermatophytoses and candidoses.皮肤癣菌病和念珠菌病的局部治疗。
Practitioner. 1975 Mar;214(1281):412-7.
4
[Evaluation of the clinical efficacy and tolerance of a formulation of 2% tioconazole cream versus 1% tioconazole cream in the treatment of dermatomycoses].[2% 噻康唑乳膏与 1% 噻康唑乳膏制剂治疗皮肤真菌病的临床疗效及耐受性评估]
G Ital Chemioter. 1988 Jan-Dec;35(1-3):69-73.
5
[Clotrimazol therapy of skin mycoses].[克霉唑治疗皮肤真菌病]
Hautarzt. 1977 Mar;28(3):140-4.
6
Croconazole: a new broad spectrum agent in the treatment of fungal skin infections.克霉唑:一种治疗皮肤真菌感染的新型广谱药物。
Int J Clin Pharmacol Res. 1994;14(4):139-48.
7
A clinical and mycological assessment of tioconazole solution in the treatment of superficial dermatomycoses.噻康唑溶液治疗浅表皮肤真菌病的临床及真菌学评估
Clin Ther. 1987;9(3):333-8.
8
[Multicenter double-blind contralateral comparison of naftifin and clotrimazole cream in patients with dermatophytosis and candidiasis].
Z Hautkr. 1984 Sep 15;59(18):1209-17.
9
[Alternative in the treatment of saccharomycoses].[酵母菌病治疗的替代方法]
Fortschr Med. 1973 Sep 13;91(25):999-1002.
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Topical treatment of dermatomycoses with Canesten cream, a new antimycotic compound.用新抗真菌化合物凯妮汀乳膏对皮肤真菌病进行局部治疗。
Mykosen. 1973 Nov 1;16(11):363-5. doi: 10.1111/j.1439-0507.1973.tb04072.x.