Filippone Claudia, Castel Guillaume, Murri Séverine, Beaulieux Frédérik, Ermonval Myriam, Jallet Corinne, Wise Emma L, Ellis Richard J, Marston Denise A, McElhinney Lorraine M, Fooks Anthony R, Desvars Amélie, Halos Lénaı G, Vourc'h Gwenaël, Marianneau Philippe, Tordo Noël
Institut Pasteur, Unité des Stratégies Antivirales, F-75015, Paris, France.
INRA, UMR 1062 CBGP, F-34988 Montferrier-sur-Lez, France and Institut de Biologie Computationnelle, 34095 Montpellier, France.
J Gen Virol. 2016 May;97(5):1060-1065. doi: 10.1099/jgv.0.000440. Epub 2016 Mar 1.
Hantaviruses are emerging zoonotic viruses that cause human diseases. In this study, sera from 642 mammals from La Réunion and Mayotte islands (Indian Ocean) were screened for the presence of hantaviruses by molecular analysis. None of the mammals from La Réunion island was positive, but hantavirus genomic RNA was discovered in 29/160 (18 %) Rattus rattus from Mayotte island. The nucleoprotein coding region was sequenced from the liver and spleen of all positive individuals allowing epidemiological and intra-strain variability analyses. Phylogenetic analysis based on complete coding genomic sequences showed that this Murinae-associated hantavirus is a new variant of Thailand virus. Further studies are needed to investigate hantaviruses in rodent hosts and in Haemorrhagic Fever with Renal Syndrome (HFRS) human cases.
汉坦病毒是引发人类疾病的新兴人畜共患病毒。在本研究中,通过分子分析对来自留尼汪岛和马约特岛(印度洋)的642只哺乳动物的血清进行了汉坦病毒检测。留尼汪岛的所有哺乳动物均未呈阳性,但在马约特岛的29/160只(18%)黑家鼠中发现了汉坦病毒基因组RNA。对所有阳性个体的肝脏和脾脏进行了核蛋白编码区测序,以进行流行病学和菌株内变异性分析。基于完整编码基因组序列的系统发育分析表明,这种与鼠亚科相关的汉坦病毒是泰国病毒的一个新变种。需要进一步研究以调查啮齿动物宿主中的汉坦病毒以及肾综合征出血热(HFRS)人类病例中的汉坦病毒。