Kariwa Hiroaki, Lokugamage Kumari, Lokugamage Nandadeva, Miyamoto Hironobu, Yoshii Kentaro, Nakauchi Mina, Yoshimatsu Kumiko, Arikawa Jiro, Ivanov Leonid I, Iwasaki Takuya, Takashima Ikuo
Laboratory of Public Health, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Jpn J Vet Res. 2007 Feb;54(4):145-61.
Hantaviruses are causative agents of some severe human illnesses, including hemorrhagic fever with renal syndrome (HFRS) and hantavirus pulmonary syndrome (HPS). The viruses are maintained by rodent hosts, and humans acquire infection by inhaling virus-contaminated excreta from infected animals. To examine the epidemiology of hantavirus infections in Japan and Far East Russia, we conducted epidemiological surveys in these regions. In Japan, anti-hantavirus antibodies were found in four rodent species, Clethrionomys rufocanus, Rattus norvegicus, R. rattus, and Apodemus speciosus. Although no new HFRS cases have been officially reported over the past 20 years in Japan, one member of the Japan Ground Self-Defense Force did test positive for hantavirus antibody. Repeated surveys in Far East Russia have revealed that two distinct hantavirus types cause severe HFRS in this region. Hantavirus sequences identified from A. peninsulae, fetal HFRS cases in Vladivostok, and Amur virus are highly similar to each other (> 92% identity), but they are less similar (approximately 84% identity) to the prototypical Hantaan virus, which is carried by A. agrarius. Phylogenetic analysis also indicates that Amur and A. peninsulae-associated viruses are distinct from Hantaan virus, suggesting that A. peninsulae is the reservoir animal for Amur virus, which causes severe HFRS. From HFRS patients in the Khabarovsk region, we identified viruses with nucleotide sequences that are more similar to Far East virus (> 96%identity) than to the Hantaan (88-89% identity) or Amur (81-83% identity) viruses. Phylogenetic analysis also indicates that the viruses from Khabarovsk HFRS patients are closely related to the Far East virus, and distinct from Amur virus.
汉坦病毒是一些严重人类疾病的病原体，包括肾综合征出血热（HFRS）和汉坦病毒肺综合征（HPS）。这些病毒以啮齿动物为宿主，人类通过吸入受感染动物的病毒污染排泄物而感染。为了研究日本和俄罗斯远东地区汉坦病毒感染的流行病学，我们在这些地区进行了流行病学调查。在日本，在四种啮齿动物中发现了抗汉坦病毒抗体，分别是棕背䶄、褐家鼠、黑家鼠和大林姬鼠。尽管在过去20年里日本没有官方报告新的HFRS病例，但日本陆上自卫队的一名成员汉坦病毒抗体检测呈阳性。在俄罗斯远东地区的反复调查显示，两种不同类型的汉坦病毒在该地区导致严重的HFRS。从远东地区的姬鼠、符拉迪沃斯托克的胎儿HFRS病例以及阿穆尔病毒中鉴定出的汉坦病毒序列彼此高度相似（>92%同源性），但它们与由黑线姬鼠携带的原型汉坦病毒的相似性较低（约84%同源性）。系统发育分析还表明，阿穆尔病毒和与远东地区姬鼠相关的病毒与汉坦病毒不同，这表明远东地区姬鼠是导致严重HFRS的阿穆尔病毒的储存宿主动物。从哈巴罗夫斯克地区的HFRS患者中，我们鉴定出的病毒核苷酸序列与远东病毒的相似性更高（>96%同源性），而与汉坦病毒（88 - 89%同源性）或阿穆尔病毒（81 - 83%同源性）的相似性较低。系统发育分析还表明，来自哈巴罗夫斯克HFRS患者的病毒与远东病毒密切相关，与阿穆尔病毒不同。
