利用协作杂交群体研究遗传多样性在癌症相关表型中的作用。
Using the Collaborative Cross to Study the Role of Genetic Diversity in Cancer-Related Phenotypes.
作者信息
Reilly Karlyne M
机构信息
Mouse Cancer Genetics Program, National Cancer Institute, Frederick, Maryland 21702.
出版信息
Cold Spring Harb Protoc. 2016 Mar 1;2016(3):pdb.prot079178. doi: 10.1101/pdb.prot079178.
Abstract
Human populations are genetically diverse and often a single mouse model can only represent a small subset of the human population. Studying genetic diversity directly can improve the predictive value of mouse models of cancer biology and research on the effects of carcinogens and therapeutics in humans. The collaborative cross is a panel of inbred mouse lines that captures 90% of the genetic diversity of the Mus musculus strain and can help identify regions of the genome that are responsible for variation in cancer phenotypes across the population. The appropriate procedure will depend on the mouse model used; here, three mouse cross designs are described as examples.
摘要
人类群体在基因上具有多样性，通常单个小鼠模型只能代表人类群体的一小部分。直接研究基因多样性可以提高癌症生物学小鼠模型以及致癌物和治疗方法对人类影响研究的预测价值。协作杂交是一组近交系小鼠，它捕获了小家鼠品系90%的基因多样性，有助于识别基因组中导致群体癌症表型变异的区域。合适的程序将取决于所使用的小鼠模型；这里，描述了三种小鼠杂交设计作为示例。
相似文献
1
Using the Collaborative Cross to Study the Role of Genetic Diversity in Cancer-Related Phenotypes.
Cold Spring Harb Protoc. 2016 Mar 1;2016(3):pdb.prot079178. doi: 10.1101/pdb.prot079178.
2
Genetic diversity in the collaborative cross model recapitulates human West Nile virus disease outcomes.
mBio. 2015 May 5;6(3):e00493-15. doi: 10.1128/mBio.00493-15.
3
Extensive Homeostatic T Cell Phenotypic Variation within the Collaborative Cross.
Cell Rep. 2017 Nov 21;21(8):2313-2325. doi: 10.1016/j.celrep.2017.10.093.
4
[The Collaborative Cross, a groundbreaking tool to tackle complex traits].
Med Sci (Paris). 2012 Jan;28(1):103-8. doi: 10.1051/medsci/2012281024. Epub 2012 Jan 27.
5
Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.
PLoS Pathog. 2013 Feb;9(2):e1003196. doi: 10.1371/journal.ppat.1003196. Epub 2013 Feb 28.
6
Genetic analysis in the Collaborative Cross breeding population.
Genome Res. 2011 Aug;21(8):1223-38. doi: 10.1101/gr.113886.110. Epub 2011 Jul 6.
7
Controlling Genetic Background in Crosses of Mouse Models of Cancer.
Cold Spring Harb Protoc. 2016 Mar 1;2016(3):pdb.prot079160. doi: 10.1101/pdb.prot079160.
8
The polymorphism architecture of mouse genetic resources elucidated using genome-wide resequencing data: implications for QTL discovery and systems genetics.
Mamm Genome. 2007 Jul;18(6-7):473-81. doi: 10.1007/s00335-007-9045-1. Epub 2007 Aug 3.
9
The Collaborative Cross mouse model for dissecting genetic susceptibility to infectious diseases.
Mamm Genome. 2018 Aug;29(7-8):471-487. doi: 10.1007/s00335-018-9768-1. Epub 2018 Aug 24.
10
Genetics of murine craniofacial morphology: diallel analysis of the eight founders of the Collaborative Cross.
J Anat. 2016 Jan;228(1):96-112. doi: 10.1111/joa.12382. Epub 2015 Oct 1.
引用本文的文献
1
Analysis of Hepatic Lentiviral Vector Transduction: Implications for Preclinical Studies and Clinical Gene Therapy Protocols.
Viruses. 2025 Feb 17;17(2):276. doi: 10.3390/v17020276.
2
Analysis of hepatic lentiviral vector transduction; implications for preclinical studies and clinical gene therapy protocols.
bioRxiv. 2024 Aug 31:2024.08.20.608805. doi: 10.1101/2024.08.20.608805.
3
Disease Animal Models for Cancer Research.
Methods Mol Biol. 2023;2645:105-125. doi: 10.1007/978-1-0716-3056-3_4.
4
Mouse population genetics phenocopies heterogeneity of human Chd8 haploinsufficiency.
Neuron. 2023 Feb 15;111(4):539-556.e5. doi: 10.1016/j.neuron.2023.01.009. Epub 2023 Feb 3.
5
LCK-Mediated RIPK3 Activation Controls Double-Positive Thymocyte Proliferation and Restrains Thymic Lymphoma by Regulating the PP2A-ERK Axis.
Adv Sci (Weinh). 2022 Nov;9(32):e2204522. doi: 10.1002/advs.202204522. Epub 2022 Sep 25.
6
Whole Genome Sequencing and Progress Toward Full Inbreeding of the Mouse Collaborative Cross Population.
G3 (Bethesda). 2019 May 7;9(5):1303-1311. doi: 10.1534/g3.119.400039.
7
Optic Pathway Gliomas in Neurofibromatosis Type 1.
J Child Neurol. 2018 Jan;33(1):73-81. doi: 10.1177/0883073817739509.
8
Extensive Homeostatic T Cell Phenotypic Variation within the Collaborative Cross.
Cell Rep. 2017 Nov 21;21(8):2313-2325. doi: 10.1016/j.celrep.2017.10.093.
9
Preclinical mouse solid tumour models: status quo, challenges and perspectives.
Nat Rev Cancer. 2017 Dec;17(12):751-765. doi: 10.1038/nrc.2017.92. Epub 2017 Oct 27.
本文引用的文献
1
Resistance to oncolytic myxoma virus therapy in nf1(-/-)/trp53(-/-) syngeneic mouse glioma models is independent of anti-viral type-I interferon.
PLoS One. 2013 Jun 6;8(6):e65801. doi: 10.1371/journal.pone.0065801. Print 2013.
2
Modeling host genetic regulation of influenza pathogenesis in the collaborative cross.
PLoS Pathog. 2013 Feb;9(2):e1003196. doi: 10.1371/journal.ppat.1003196. Epub 2013 Feb 28.
3
A genetic approach to the prediction of drug side effects: bleomycin induces concordant phenotypes in mice of the collaborative cross.
Pharmgenomics Pers Med. 2011;4:35-45. doi: 10.2147/PGPM.S22475. Epub 2011 Jul 4.
4
Genetic analysis of albuminuria in collaborative cross and multiple mouse intercross populations.
Am J Physiol Renal Physiol. 2012 Oct;303(7):F972-81. doi: 10.1152/ajprenal.00690.2011. Epub 2012 Aug 1.
5
Host genetic and environmental effects on mouse intestinal microbiota.
ISME J. 2012 Nov;6(11):2033-44. doi: 10.1038/ismej.2012.54. Epub 2012 Jun 14.
6
Expression quantitative trait Loci for extreme host response to influenza a in pre-collaborative cross mice.
G3 (Bethesda). 2012 Feb;2(2):213-21. doi: 10.1534/g3.111.001800. Epub 2012 Feb 1.
7
Genetic analysis of hematological parameters in incipient lines of the collaborative cross.
G3 (Bethesda). 2012 Feb;2(2):157-65. doi: 10.1534/g3.111.001776. Epub 2012 Feb 1.
8
The genome architecture of the Collaborative Cross mouse genetic reference population.
Genetics. 2012 Feb;190(2):389-401. doi: 10.1534/genetics.111.132639.
9
Ten years of the Collaborative Cross.
Genetics. 2012 Feb;190(2):291-4. doi: 10.1534/genetics.111.138032.
10
Advances in comparative genetics: influence of genetics on obesity.
Br J Nutr. 2011 Oct;106 Suppl 1:S1-10. doi: 10.1017/S0007114511001905.
Zotero 插件