利用协作杂交群体研究遗传多样性在癌症相关表型中的作用。
Using the Collaborative Cross to Study the Role of Genetic Diversity in Cancer-Related Phenotypes.
作者信息
Reilly Karlyne M
机构信息
Mouse Cancer Genetics Program, National Cancer Institute, Frederick, Maryland 21702.
出版信息
Cold Spring Harb Protoc. 2016 Mar 1;2016(3):pdb.prot079178. doi: 10.1101/pdb.prot079178.
Abstract
Human populations are genetically diverse and often a single mouse model can only represent a small subset of the human population. Studying genetic diversity directly can improve the predictive value of mouse models of cancer biology and research on the effects of carcinogens and therapeutics in humans. The collaborative cross is a panel of inbred mouse lines that captures 90% of the genetic diversity of the Mus musculus strain and can help identify regions of the genome that are responsible for variation in cancer phenotypes across the population. The appropriate procedure will depend on the mouse model used; here, three mouse cross designs are described as examples.
摘要
人类群体在基因上具有多样性，通常单个小鼠模型只能代表人类群体的一小部分。直接研究基因多样性可以提高癌症生物学小鼠模型以及致癌物和治疗方法对人类影响研究的预测价值。协作杂交是一组近交系小鼠，它捕获了小家鼠品系90%的基因多样性，有助于识别基因组中导致群体癌症表型变异的区域。合适的程序将取决于所使用的小鼠模型；这里，描述了三种小鼠杂交设计作为示例。
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