治疗早发型帕金森病的多巴胺能药物节省策略
DOPA-sparing strategy in the treatment of young onset Parkinson's disease.
作者信息
Rana Abdul Qayyum, Saleh Mohamad, Yousuf Muhammad Saad, Mansoor Wasim, Hussaini Syed, Rahman Maniza, Iqbal Zohair
机构信息
Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada.
Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada; Centre for Neuroscience, University of Alberta, Edmonton, Canada.
出版信息
J Neurosci Rural Pract. 2016 Jan-Mar;7(1):67-9. doi: 10.4103/0976-3147.172155.
CONTEXT
Late onset Parkinson's disease (LOPD) is a neurodegenerative disorder afflicting individuals of ages 60 and older. However, 5-10% of cases can begin earlier between the ages 20 to 40, and are classified as young onset Parkinson disease (YOPD).
AIM
In turn, this study aims to observe the trend in the choice of drug administered to patients with both YOPD and LOPD, with particular emphasis on this trend in its relation to the practice background of the neurologist.
SETTINGS AND DESIGN
A cross-sectional study was conducted in a community based Parkinson's disease and movement disorder clinic.
STATISTICAL ANALYSIS USED
Using a retrospective chart review data was obtained and analysed.
RESULTS
The results showed that 83% of general neurologists prescribed levodopa to their patients with YOPD, whereas movement-disorder specialists took a different approach altogether. They opted not to use levodopa and, in its stead, prescribed a mixture of alternate drugs.
背景
晚发型帕金森病（LOPD）是一种折磨60岁及以上人群的神经退行性疾病。然而，5% - 10%的病例在20至40岁之间发病更早，被归类为青年型帕金森病（YOPD）。
目的
相应地，本研究旨在观察YOPD和LOPD患者用药选择的趋势，特别强调这种趋势与神经科医生的执业背景之间的关系。
设置与设计
在一个社区帕金森病和运动障碍诊所进行了一项横断面研究。
所用统计分析方法
通过回顾性病历审查获取并分析数据。
结果
结果显示，83%的普通神经科医生为他们的YOPD患者开左旋多巴，而运动障碍专科医生则采取了完全不同的方法。他们选择不使用左旋多巴，而是开了一种替代药物的混合物。
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