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生化和免疫学参数作为骨关节炎患者的指标：羟基胶原在自身抗体产生中的作用

Biochemical and immunological parameters as indicators of osteoarthritis subjects: role of OH-collagen in auto-antibodies generation.

作者信息

Ashraf Jalaluddin M, Haque Quazi S, Tabrez Shams, Choi Inho, Ahmad Saheem

机构信息

School of Biotechnology, Yeungnam University, Gyeongsan, Republic of Korea.

Department of Biochemistry, Hind Institute of Medical Sciences, Barabanki, U.P., India.

出版信息

EXCLI J. 2015 Sep 23;14:1057-66. doi: 10.17179/excli2014-423. eCollection 2015.

DOI:10.17179/excli2014-423
PMID:26933405
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4763472/
Abstract

Osteoarthritis (OA) is characterized by inflammation of the knee joint, which is caused by accumulation of cytokines and C-reactive protein (CRP) in the extracellular matrix as an early immune response to infection. The articular cartilage destruction is discernible by elevated tumour necrosis factor-α (TNF-α). In this study, blood samples of knee osteoarthritis patients were analyzed for biochemical and physiological parameters based on the lipid profile, uric acid, total leukocyte count (TLC), hemoglobin percentage (Hb%) and absolute lymphocyte count (ALC). Furthermore, immunological parameters including TNF-α , interleukin-6 (IL-6) and CRP were analyzed. The presence of antibodies against hydroxyl radical modified collagen-II ((•)OH-collagen-II) was also investigated in arthritis patients using direct binding ELISA. The uric acid and lipid profiles changed extensively. Specifically, increased uric acid levels were associated with OA in both genders, as were enhanced immunological parameters. The TNF-α level also increased in both genders suffering from OA. Finally, auto-antibodies against OH-collagen II antigen were found in the sera of arthritis patients. These results indicated that immunological parameters are better predictors or indexes for diagnosis of OA than biochemical parameters.

摘要

骨关节炎（OA）的特征是膝关节炎症，这是由细胞因子和C反应蛋白（CRP）在细胞外基质中积累引起的，作为对感染的早期免疫反应。肿瘤坏死因子-α（TNF-α）升高可 discernible 关节软骨破坏。在本研究中，对膝关节骨关节炎患者的血液样本进行了分析，以检测基于血脂谱、尿酸、白细胞总数（TLC）、血红蛋白百分比（Hb%）和绝对淋巴细胞计数（ALC）的生化和生理参数。此外，还分析了包括TNF-α、白细胞介素-6（IL-6）和CRP在内的免疫参数。还使用直接结合ELISA研究了关节炎患者中抗羟基自由基修饰的胶原蛋白-II（（•）OH-胶原蛋白-II）抗体的存在。尿酸和血脂谱发生了广泛变化。具体而言，尿酸水平升高与男女OA均相关，免疫参数增强也与之相关。患OA的男女TNF-α水平也升高。最后，在关节炎患者血清中发现了针对OH-胶原蛋白II抗原的自身抗体。这些结果表明，免疫参数比生化参数更适合作为OA诊断的预测指标或指标。 （注：“discernible”此处翻译可能不准确，需结合上下文进一步确认准确含义后调整）

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27b5/4763472/3c3d5e902b7c/EXCLI-14-1057-t-006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27b5/4763472/d1a461903104/EXCLI-14-1057-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27b5/4763472/536281fb353f/EXCLI-14-1057-t-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27b5/4763472/e352b9c64a55/EXCLI-14-1057-t-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27b5/4763472/05f6f9ac8dab/EXCLI-14-1057-t-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27b5/4763472/2be87770949f/EXCLI-14-1057-t-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27b5/4763472/3c3d5e902b7c/EXCLI-14-1057-t-006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27b5/4763472/d1a461903104/EXCLI-14-1057-t-001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27b5/4763472/536281fb353f/EXCLI-14-1057-t-002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27b5/4763472/e352b9c64a55/EXCLI-14-1057-t-003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27b5/4763472/05f6f9ac8dab/EXCLI-14-1057-t-004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27b5/4763472/2be87770949f/EXCLI-14-1057-t-005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/27b5/4763472/3c3d5e902b7c/EXCLI-14-1057-t-006.jpg

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