Alshami Mohammad Ali, Mohana Mona Jameel
Dermatology Department, University Hospital, Sana'a University, Sana'a, Yemen.
Case Rep Dermatol. 2016 Jan 20;8(1):5-9. doi: 10.1159/000443824. eCollection 2016 Jan-Apr.
Kyrle disease (KD) and Flegel disease (FD) are rare variants of primary perforating dermatoses, characterized by transepidermal elimination of abnormal endogenous materials. We describe a 6-year-old Yemeni girl with a 2-year history of generalized asymptomatic, small, reddish-brown keratotic papules with a lenticular central keratotic plug. Although these features are synonymous with FD, the histology of a punch biopsy was consistent with KD. The patient was otherwise healthy, and no family members had a history of similar diseases. The patient was diagnosed with KD-FD, owing to the manifestation of features associated with both diseases.
Kyrle病（KD）和Flegel病（FD）是原发性穿通性皮肤病的罕见变体，其特征是异常内源性物质经表皮排出。我们描述了一名6岁的也门女孩，有2年全身性无症状、小的红棕色角化丘疹病史，丘疹中央有透镜状角质栓。虽然这些特征与FD同义，但钻孔活检的组织学表现与KD一致。该患者其他方面健康，且家庭成员无类似疾病史。由于同时出现了与两种疾病相关的特征，该患者被诊断为KD-FD。
