Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Structural Genomics Consortium, Nuffield Department of Medicine, University of Oxford, Old Road Campus Research Building, Roosevelt Drive, Oxford OX3 7DQ, UK.
Cell Chem Biol. 2016 Jan 21;23(1):173-182. doi: 10.1016/j.chembiol.2015.12.005.
The continual improvement in our ability to generate high resolution structural models of biological molecules has stimulated and supported innovative chemical biology projects that target increasingly challenging ligand interaction sites. In this review we outline some of the recent developments in chemical biology and rational ligand design and show selected examples that illustrate the synergy between these research areas.
我们生成生物分子高分辨率结构模型的能力不断提高，这激发并支持了创新性的化学生物学项目，这些项目针对的是越来越具有挑战性的配体相互作用位点。在这篇综述中，我们概述了化学生物学和合理配体设计的一些最新进展，并展示了一些例子来说明这些研究领域之间的协同作用。
