Romano Vito, Steger Bernhard, Kovacova Adriana, Kaye Stephen B, Willoughby Colin E
a Department of Corneal and External Eye Diseases, St. Paul's Eye Unit , Royal Liverpool University Hospital , Liverpool , UK.
b Department of Ophthalmology , Medical University of Innsbruck , Innsbruck , Austria.
Ophthalmic Genet. 2016 Dec;37(4):434-436. doi: 10.3109/13816810.2015.1111911. Epub 2016 Mar 2.
Epidemiological reports strongly indicate that pterygium is an ophthalmoheliosis: a sun-related eye disease. Familial occurrence of pterygium is rare but supports the concept that heredity may predispose the conjunctiva to react abnormally to atmospheric-environmental stimuli. We describe a two generation Caucasian family of five members from the United Kingdom, four of whom developed pterygia in early adulthood with autosomal dominant inheritance. The present report confirms the significance of heredity in the pathogenesis of pterygium. Understanding the genetic basis of pterygium pathogenesis is clinically relevant, particularly in the management of patients who develop recurrent and aggressive pterygia at younger ages.
流行病学报告有力地表明，翼状胬肉是一种光性眼疾病：一种与阳光相关的眼部疾病。翼状胬肉的家族性发病罕见，但支持这样一种观点，即遗传可能使结膜易于对大气环境刺激产生异常反应。我们描述了一个来自英国的两代五口白种人家庭，其中四人在成年早期患翼状胬肉，呈常染色体显性遗传。本报告证实了遗传在翼状胬肉发病机制中的重要性。了解翼状胬肉发病机制的遗传基础具有临床相关性，特别是在管理那些在年轻时就出现复发性和侵袭性翼状胬肉的患者时。
