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人类胃癌诊断中的潜在生物标志物

Potential Biomarkers in Diagnosis of Human Gastric Cancer.

作者信息

Zhang Zhihao, Dou Mengmeng, Yao Xiaofang, Tang Hao, Li Zhubo, Zhao Xiaoyan

机构信息

a College of Pharmaceutical Sciences, Southwest University , Chongqing , China.

出版信息

Cancer Invest. 2016;34(3):115-22. doi: 10.3109/07357907.2015.1114122. Epub 2016 Mar 2.

DOI:10.3109/07357907.2015.1114122
PMID:26934336
Abstract

The high incidence of gastric cancer (GC) and its consequent mortality rate severely threaten human's health. It is not frequently diagnosed until a relatively advanced stage. Surgery is the only potentially curative treatment. Thus, early screening and diagnosis are critical for patients with GC. The tumor marker assays used currently for detecting GC are simple and rapid, but the usage is limited by its low sensitivity and specificity. Here, we provide a brief description of some new potential markers and new biotechnological methods for the diagnosis of GC, hoping to find out more effective approaches for early detection of GC.

摘要

胃癌(GC)的高发病率及其随之而来的死亡率严重威胁着人类健康。直到相对晚期才经常被诊断出来。手术是唯一可能治愈的治疗方法。因此,早期筛查和诊断对胃癌患者至关重要。目前用于检测胃癌的肿瘤标志物检测方法简单快速,但因其低敏感性和特异性而应用受限。在此,我们简要介绍一些用于胃癌诊断的新的潜在标志物和新的生物技术方法,希望能找到更有效的早期检测胃癌的方法。

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