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定义成人单纯性慢性鼻-鼻窦炎治疗中鼻内镜鼻窦手术的适宜性标准:一项兰德公司/加州大学洛杉矶分校适宜性研究

Defining appropriateness criteria for endoscopic sinus surgery during management of uncomplicated adult chronic rhinosinusitis: a RAND/UCLA appropriateness study.

作者信息

Rudmik Luke, Soler Zachary M, Hopkins Claire, Schlosser Rodney J, Peters Anju, White Andrew A, Orlandi Richard R, Fokkens Wytske J, Douglas Richard, Smith Timothy L

机构信息

Division of Otolaryngology, Head and Neck Surgery, Department of Surgery, University of Calgary, Calgary, AB, Canada.

Division of Rhinology and Sinus Surgery, Department of Otolaryngology, Head and Neck Surgery, Medical University of South Carolina; Charleston, SC, USA.

出版信息

Rhinology. 2016 Jun;54(2):117-28. doi: 10.4193/Rhino16.023.

Abstract

INTRODUCTION

Appropriate indications for endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) are currently poorly defined. The lack of clear surgical indications for ESS likely contributes to the large geographic variation in surgical rates and contributes to reduced quality of care. The objective of this study was to define appropriateness criteria for ESS during management of adult patients with uncomplicated CRS.

METHODS

The RAND/UCLA appropriateness methodology was performed. An international, multi-disciplinary panel of 10 experts in CRS was formed and completed two rounds of a modified Delphi ranking process along with a face-to-face meeting.

RESULTS

A total of 624 clinical scenarios were ranked, 312 scenarios each for CRS with and CRS without nasal polyps. For adult patients with uncomplicated CRS with nasal polyps, ESS can be appropriately offered when the CT Lund-Mackay score is ≥ 1 and there has been a minimum trial of a topical intranasal corticosteroid plus a short-course of systemic corticosteroid with a post-treatment total SNOT-22 score ≥ 20. For adult patients with uncomplicated CRS without nasal polyps, ESS can be appropriately offered when the CT Lund-Mackay score is ≥ 1 and there has been a minimum trial of a topical intranasal corticosteroid plus either a short-course of a broad spectrum/culture-directed systemic antibiotic or the use of a prolonged course of systemic low-dose anti-inflammatory antibiotic with a post-treatment total SNOT-22 score ≥ 20.

CONCLUSION

This study has developed and reported of list of appropriateness criteria to offer ESS as a treatment option during management of uncomplicated adult CRS. The extent or technique of ESS was not addressed in this study and will depend on surgeon and patient factors. Furthermore, these criteria are the minimal threshold to make ESS a treatment option and do not imply that all patients meeting these criteria require surgery. The decision to perform ESS should be made after an informed patient makes a preference-sensitive decision to proceed with surgery. Applying these appropriateness criteria for ESS may optimize patient selection, reduce the incidence of unwarranted surgery, and assist clinicians in providing high quality, patient-centered care to patients with CRS.

摘要

引言

目前,慢性鼻-鼻窦炎(CRS)内镜鼻窦手术(ESS)的恰当适应证尚不明确。ESS缺乏明确的手术适应证,这可能是导致手术率在地域上存在巨大差异的原因之一,也会致使医疗质量下降。本研究的目的是确定成人单纯性CRS治疗过程中ESS的恰当性标准。

方法

采用兰德/加州大学洛杉矶分校恰当性方法。组建了一个由10名CRS国际多学科专家组成的小组,并完成了两轮改进的德尔菲排序过程以及一次面对面会议。

结果

共对624种临床情况进行了排序,其中有鼻息肉的CRS和无鼻息肉的CRS各312种情况。对于成人单纯性CRS伴鼻息肉患者,当CT Lund-Mackay评分≥1,且至少尝试过局部鼻内糖皮质激素加短期全身性糖皮质激素治疗,治疗后SNOT-22总分≥20时,可以适当进行ESS。对于成人单纯性CRS不伴鼻息肉患者,当CT Lund-Mackay评分≥1,且至少尝试过局部鼻内糖皮质激素加短期广谱/根据培养结果选用的全身性抗生素治疗,或使用延长疗程的全身性低剂量抗炎抗生素治疗,治疗后SNOT-22总分≥20时,可以适当进行ESS。

结论

本研究制定并报告了在成人单纯性CRS治疗过程中,将ESS作为一种治疗选择的恰当性标准清单。本研究未涉及ESS的范围或技术,这将取决于外科医生和患者因素。此外,这些标准是使ESS成为一种治疗选择的最低阈值,并不意味着所有符合这些标准的患者都需要手术。是否进行ESS的决定应在患者做出知情的、偏好敏感的手术决定后做出。应用这些ESS恰当性标准可能会优化患者选择,降低不必要手术的发生率,并帮助临床医生为CRS患者提供高质量的、以患者为中心的医疗服务。

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