Rudmik Luke, Soler Zachary M, Hopkins Claire, Schlosser Rodney J, Peters Anju, White Andrew A, Orlandi Richard R, Fokkens Wytske J, Douglas Richard, Smith Timothy L
Division of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Calgary, Calgary, Alberta, Canada.
Division of Rhinology and Sinus Surgery, Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC.
Int Forum Allergy Rhinol. 2016 Jun;6(6):557-67. doi: 10.1002/alr.21769. Epub 2016 Mar 11.
Appropriate indications for endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS) are currently poorly defined. The lack of clear surgical indications for ESS likely contributes to the large geographic variation in surgical rates and contributes to reduced quality of care. The objective of this study was to define appropriateness criteria for ESS during management of adult patients with uncomplicated CRS.
The RAND/UCLA appropriateness methodology was performed. An international, multidisciplinary panel of 10 experts in CRS was formed and completed 2 rounds of a modified Delphi ranking process along with a face-to-face meeting.
A total of 624 clinical scenarios were ranked, 312 scenarios each for CRS with and CRS without nasal polyps. For adult patients with uncomplicated CRS with nasal polyps, ESS can be appropriately offered when the CT Lund-Mackay score is ≥ 1 and there has been a minimum trial of a topical intranasal corticosteroid plus a short-course of systemic corticosteroid with a post-treatment total SNOT-22 score ≥ 20. For adult patients with uncomplicated CRS without nasal polyps, ESS can be appropriately offered when the CT Lund-Mackay score is ≥ 1 and there has been a minimum trial of a topical intranasal corticosteroid plus either a short-course of a broad spectrum/culture-directed systemic antibiotic or the use of a prolonged course of systemic low-dose anti-inflammatory antibiotic with a post-treatment total SNOT-22 score ≥ 20.
This study has developed and reported of list of appropriateness criteria to offer ESS as a treatment "option" during management of uncomplicated adult CRS. The extent or technique of ESS was not addressed in this study and will depend on surgeon and patient factors. Furthermore, these criteria are the minimal threshold to make ESS a treatment "option" and do not imply that all patients meeting these criteria require surgery. The decision to perform ESS should be made after an informed patient makes a preference-sensitive decision to proceed with surgery. Applying these appropriateness criteria for ESS may optimize patient selection, reduce the incidence of unwarranted surgery, and assist clinicians in providing high-quality, patient-centered care to patients with CRS.
目前,慢性鼻-鼻窦炎(CRS)行鼻内镜鼻窦手术(ESS)的恰当适应证定义尚不明确。ESS缺乏明确的手术适应证,这可能是导致手术率在地域上差异巨大的原因,也致使医疗质量下降。本研究的目的是确定在成年单纯性CRS患者管理过程中ESS的恰当性标准。
采用兰德/加州大学洛杉矶分校恰当性方法。组建了一个由10名CRS领域国际多学科专家组成的小组,完成了两轮改进的德尔菲排名过程以及一次面对面会议。
共对624种临床情况进行了排名,其中伴有鼻息肉的CRS和不伴有鼻息肉的CRS各312种情况。对于成年单纯性CRS伴鼻息肉患者,当CT Lund-Mackay评分≥1,且至少试用过鼻内局部糖皮质激素加短期全身用糖皮质激素,治疗后SNOT-22总分≥20时,可适当考虑行ESS。对于成年单纯性CRS不伴鼻息肉患者,当CT Lund-Mackay评分≥1,且至少试用过鼻内局部糖皮质激素加短期广谱/根据培养结果选用的全身用抗生素,或使用过长期低剂量全身用抗炎抗生素,治疗后SNOT-22总分≥20时,可适当考虑行ESS。
本研究制定并报告了在成年单纯性CRS管理过程中作为治疗“选择”提供ESS的恰当性标准清单。本研究未涉及ESS的范围或技术,这将取决于外科医生和患者因素。此外,这些标准是使ESS成为治疗“选择”的最低阈值,并不意味着所有符合这些标准的患者都需要手术。是否进行ESS的决定应在患者做出偏好敏感的手术决定并充分知情后做出。应用这些ESS恰当性标准可能会优化患者选择,降低不必要手术的发生率,并帮助临床医生为CRS患者提供高质量的、以患者为中心的医疗服务。