Shapiro L, Gober J W
Department of Microbiology, College of Physicians & Surgeons, Columbia University, New York, NY 10032.
J Cell Sci Suppl. 1989;11:85-97. doi: 10.1242/jcs.1989.supplement_11.7.
Caulobacter crescentus has one of the simplest known developmental programs that exhibits both temporal and spatial organization. A hallmark of the Caulobacter cell cycle is that the progeny cells that result from each cell division differ from one another with respect to structure and developmental program. The process of establishing asymmetry prior to cell division requires that a number of gene products be targeted to a pole of the predivisional cell and consequently segregated to one of the two progeny. Several products involved in flagellar biogenesis and the chemotaxis machinery are segregated to the swarmer cell. Evidence suggests that the protein product of some fla and che genes is targeted to the incipient swarmer cell pole. In the case of other flagellar genes, it is the mRNA that is apparently segregated to the swarmer cell. Two heat shock proteins, DnaK and Lon are specifically segregated to the progeny stalked cell.
新月柄杆菌具有已知最简单的发育程序之一，该程序展现出时间和空间组织。柄杆菌细胞周期的一个标志是，每次细胞分裂产生的子代细胞在结构和发育程序方面彼此不同。在细胞分裂前建立不对称性的过程要求许多基因产物被靶向到分裂前细胞的一个极，从而被分配到两个子代细胞之一。一些参与鞭毛生物合成和趋化机制的产物被分配到游动细胞。有证据表明，一些鞭毛（fla）基因和趋化（che）基因的蛋白质产物被靶向到初始游动细胞极。对于其他鞭毛基因，显然是mRNA被分配到游动细胞。两种热休克蛋白，DnaK和Lon，特异性地被分配到子代柄细胞。
