Bouillet B, Gautier T, Aho L S, Duvillard L, Petit J-M, Lagrost L, Vergès B
Endocrinology, Diabetology department, University Hospital of Dijon, 2, boulevard du Maréchal-de-Lattre-de-Tassigny, BP 77908, 21079 Dijon, France; INSERM UMR 866, University of Bourgogne, Dijon, France.
INSERM UMR 866, University of Bourgogne, Dijon, France.
Diabetes Metab. 2016 Sep;42(4):263-6. doi: 10.1016/j.diabet.2016.01.003. Epub 2016 Feb 28.
Apolipoprotein C1 (apoC1) is likely to play an important role in triglyceride (TG) metabolism. Mice overexpressing human apoC1 present decreased adipose tissue stores. This study aimed to determine whether apoC1 concentration influences fat mass and distribution and liver fat content (LFC) in patients with type 2 diabetes (T2D).
ApoC1 concentrations were measured by ELISA in 113 T2D patients and 56 normolipidaemic-normoglycaemic subjects. Visceral and subcutaneous fat areas were determined by single-slice axial T1-weighted magnetic resonance imaging (MRI), while LFC was measured by hydrogen-1 ((1)H) MR spectroscopy.
ApoC1 concentrations were higher in T2D patients than in normolipidaemic-normoglycaemic subjects (P<0.0001), and did not correlate with visceral or subcutaneous fat areas, but significantly correlated with TG (P<0.0001) and LFC (P=0.02) in T2D patients. However, the correlation between apoC1 and LFC was lost after adjusting for TG. ApoC1 concentration was also significantly higher in T2D patients with TG<1.5mmol/L than in control subjects (P<0.0001), although both groups had similar TG levels. On multivariate analysis performed in T2D patients with TG<1.5mmol/L and control subjects, apoC1 concentration was independently and positively associated with type 2 diabetes (P<0.0001) and TG levels (P=0.03).
This study reports, for the first time, that apoC1 is increased in T2D patients and is significantly correlated with TG, whereas no association was found between apoC1 and adipose tissue. This indicates that, in T2D, apoC1 may play a role in TG metabolism, but is unlikely to modulate fat mass and distribution. This increased apoC1 concentration in T2D patients is not only explained by the increased TG level in T2D patients.
载脂蛋白C1（apoC1）可能在甘油三酯（TG）代谢中发挥重要作用。过表达人apoC1的小鼠脂肪组织储存减少。本研究旨在确定apoC1浓度是否影响2型糖尿病（T2D）患者的脂肪量和分布以及肝脏脂肪含量（LFC）。
通过酶联免疫吸附测定法（ELISA）测量了113例T2D患者和56例血脂正常、血糖正常的受试者的apoC1浓度。通过单层面轴向T1加权磁共振成像（MRI）确定内脏和皮下脂肪面积，而通过氢-1（（1）H）磁共振波谱测量LFC。
T2D患者的apoC1浓度高于血脂正常、血糖正常的受试者（P<0.0001），且与内脏或皮下脂肪面积无相关性，但与T2D患者的TG（P<0.0001）和LFC（P=0.02）显著相关。然而，在调整TG后，apoC1与LFC之间的相关性消失。TG<1.5mmol/L的T2D患者的apoC1浓度也显著高于对照组受试者（P<0.0001），尽管两组的TG水平相似。在TG<1.5mmol/L的T2D患者和对照组受试者中进行多变量分析时，apoC1浓度与2型糖尿病（P<0.0001）和TG水平（P=0.03）独立且呈正相关。
本研究首次报道，T2D患者的apoC1升高且与TG显著相关，而未发现apoC1与脂肪组织之间存在关联。这表明，在T2D中，apoC1可能在TG代谢中起作用，但不太可能调节脂肪量和分布。T2D患者中这种升高的apoC1浓度不仅由T2D患者中升高的TG水平所解释。
