Nguyen Brian T, Ingram Andrew J, Muller Gilles
Department of Chemistry, San José State University, San José, California, USA.
Department of Chemistry, University of Illinois Urbana-Champaign, Urbana, IL.
Chirality. 2016 Apr;28(4):325-31. doi: 10.1002/chir.22584. Epub 2016 Mar 3.
Helical D3 tris(4-amino-2,6-pyridine-dicarboxylate)terbium(III) and europium(III) complexes, which form a racemic equilibrium in aqueous solution, were prepared to study their secondary coordination sphere interactions with chiral amino acids. These interactions were probed using a combination of circularly polarized luminescence (CPL) and 13C NMR spectroscopy. The results indicate that, regardless of the interaction between the chiral molecule and the complex, without an accessible hydrogen-bond donor on the associating molecule, perturbation of the racemic equilibrium cannot occur. A generalized conclusion is established that indicates that the mechanism of chiral recognition by tris(dipicolinate)lanthanide(III) complexes is similar across a variety of analogous ligands.
制备了在水溶液中形成外消旋平衡的螺旋状D3三（4-氨基-2,6-吡啶二甲酸酯）铽（III）和铕（III）配合物，以研究它们与手性氨基酸的二级配位球相互作用。使用圆偏振发光（CPL）和13C NMR光谱相结合的方法对这些相互作用进行了探究。结果表明，无论手性分子与配合物之间的相互作用如何，如果缔合分子上没有可及的氢键供体，外消旋平衡就不会受到扰动。建立了一个一般性结论，表明三（吡啶二甲酸）镧系（III）配合物的手性识别机制在各种类似配体中是相似的。
