遗传性良性上皮内角化不良的超微结构研究

Ultrastructural study of hereditary benign intraepithelial dyskeratosis.

作者信息

Sadeghi E M, Witkop C J

出版信息

Oral Surg Oral Med Oral Pathol. 1977 Oct;44(4):567-77. doi: 10.1016/0030-4220(77)90300-0.

Abstract

Specimens taken from the buccal mucosa of two patients with hereditary benign intraepithelial dyskeratosis (HBID) were studied with the transmission electron microscope. Ultrastructural features were described and compared with those of white sponge nevus and Darier's disease. Ultrastructural findings in HBID revealed the presence of numerous vesicular bodies in immature dyskeratotic cells, densely packed tonofilaments filling the cytoplasm of mature dyskeratotic cells, and the disappearance of cellular interdigitations and desmosomes in mature dyskeratotic cells.

摘要

对两名患有遗传性良性上皮内角化不良（HBID）患者的颊黏膜标本进行了透射电子显微镜研究。描述了超微结构特征，并与白色海绵状痣和毛囊角化病的特征进行了比较。HBID的超微结构发现显示，未成熟的角化不良细胞中有大量囊泡体，成熟的角化不良细胞的细胞质中充满了密集排列的张力细丝，并且成熟的角化不良细胞中的细胞交错和桥粒消失。