Hoare T J, Jayne D, Rhys Evans P, Croft C B, Howard D J
Royal National Throat Nose and Ear Hospital, London.
J Laryngol Otol. 1989 Dec;103(12):1187-91. doi: 10.1017/s0022215100111314.
Wegener's granulomatosis is difficult to diagnose, especially when the presentation is unusual, restricted to an isolated region. We report four cases of recurrent subglottic stenosis posing difficulty in diagnosis. In each case the finding of anti-neutrophil cytoplasm antibodies (ANCA) strongly suggested an underlying vasculitic pathology, Wegener's granulomatosis. We discuss reasons for the difficulty in diagnosis in the past, the possible role of the ANCA assay in such patients, and suggest it should be more widely used in the future.
韦格纳肉芽肿病很难诊断，尤其是当临床表现不寻常且局限于孤立区域时。我们报告了4例复发性声门下狭窄病例，诊断存在困难。在每例病例中，抗中性粒细胞胞浆抗体（ANCA）检测结果强烈提示存在潜在的血管炎性病变，即韦格纳肉芽肿病。我们讨论了过去诊断困难的原因、ANCA检测在这类患者中的可能作用，并建议未来应更广泛地应用该检测。
