Nishigori Tatsuto, Okabe Hiroshi, Tanaka Eiji, Tsunoda Shigeru, Hisamori Shigeo, Sakai Yoshiharu
Department of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Department of Surgery, Otsu Municipal Hospital, Shiga, Japan.
J Surg Oncol. 2016 May;113(6):678-84. doi: 10.1002/jso.24214. Epub 2016 Mar 3.
Sarcopenia or loss of skeletal muscle mass has been identified as a poor prognostic factor for a wide variety of diseases and conditions. We investigated whether preoperative sarcopenia is associated with postoperative complications in patients undergoing esophagectomy for thoracic esophageal cancer.
We retrospectively reviewed the medical records of consecutive patients with thoracic esophageal cancer who underwent esophagectomy between September 2005 and July 2014 at Kyoto University Hospital. Skeletal muscle mass was assessed using preoperative computed tomographic scans by measuring the cross-sectional muscle area at the third lumbar vertebral level.
Among the 199 eligible patients, 149 (75%) were classified as having sarcopenia. There was no difference in the incidence of overall complications between the groups (risk ratio [RR]: 1.10, 95% confidence interval [CI]: 0.80-1.53, P = 0.54). However, pulmonary complications were significantly more frequent in the sarcopenia group than in the nonsarcopenia group (RR: 2.63, 95% CI: 1.20-5.77, P = 0.007). Multivariate analyses demonstrated that sarcopenia was associated with a high adjusted risk of one or more pulmonary complications (odds ratio: 2.96, 95% CI: 1.14-7.69, P = 0.026).
Sarcopenia independently predicts pulmonary complications after esophagectomy for thoracic esophageal cancer. J. Surg. Oncol. 2016;113:678-684. © 2016 Wiley Periodicals, Inc.
肌肉减少症或骨骼肌质量的丧失已被确定为多种疾病和病症的不良预后因素。我们调查了术前肌肉减少症是否与胸段食管癌患者食管切除术后的并发症相关。
我们回顾性分析了2005年9月至2014年7月在京都大学医院接受食管切除术的连续性胸段食管癌患者的病历。通过术前计算机断层扫描测量第三腰椎水平的肌肉横截面积来评估骨骼肌质量。
在199例符合条件的患者中，149例（75%）被归类为患有肌肉减少症。两组之间总体并发症的发生率没有差异（风险比[RR]：1.10，95%置信区间[CI]：0.80 - 1.53，P = 0.54）。然而，肌肉减少症组的肺部并发症明显比非肌肉减少症组更频繁（RR：2.63，95% CI：1.20 - 5.77，P = 0.007）。多因素分析表明，肌肉减少症与一种或多种肺部并发症的高调整风险相关（优势比：2.96，95% CI：1.14 - 7.69，P = 0.026）。
肌肉减少症独立预测胸段食管癌食管切除术后的肺部并发症。《外科肿瘤学杂志》2016年；113：678 - 684。© 2016威利期刊公司
