Hirahara K, Saitoh T, Terada I, Uno K, Nagai A, Kioi S, Arakawa M
Nihon Kyobu Shikkan Gakkai Zasshi. 1989 Oct;27(10):1231-6.
A case of pneumonitis due to Serrapeptase was described. A 69-year-old man was treated with Serrapeptase for 16 days because of common cold, then fever, nonproductive cough and dyspnea developed and chest X-ray revealed diffuse fine granular shadows in bilateral lung fields. Once the administration of Serrapeptase was halted, symptoms, chest X-ray abnormalities and laboratory data improved markedly. The fraction of lymphocytes increased in bronchoalveolar lavage fluid and OKT4/T8 decreased. Microscopic examination of transbronchial lung biopsy showed interstitial pneumonia. Both leukocyte migration inhibition test and sensitized hemagglutination test were positive for Serrapeptase. Based on these findings, we diagnosed this case as Serrapeptase-induced pneumonitis.
报告了1例由舍雷肽酶引起的肺炎病例。一名69岁男性因普通感冒接受舍雷肽酶治疗16天，随后出现发热、干咳和呼吸困难，胸部X线显示双侧肺野弥漫性细颗粒状阴影。停用舍雷肽酶后，症状、胸部X线异常及实验室检查结果明显改善。支气管肺泡灌洗液中淋巴细胞比例增加，OKT4/T8降低。经支气管肺活检的显微镜检查显示为间质性肺炎。白细胞游走抑制试验和致敏血凝试验对舍雷肽酶均呈阳性。基于这些发现，我们将该病例诊断为舍雷肽酶诱发的肺炎。
