Razumova E T, Volov N A, Savenkov P M, Grigo'reva T V, Aleksandrova E G, Shitikova L V, Tatarenkova L V, Sarkisov A M
Kardiologiia. 1989 Oct;29(10):83-8.
The two agents beta-methyldigoxin (medixin), a Soviet medilazide, and bemecor (digicor), a foreign analogue (LEK, Yugoslavia) were comparatively evaluated. An equal high (85%) clinical efficacy of the drugs was found in 81 patients with varying stages of heart failure. A positive therapeutic effect was accompanied by lower heart rate, higher diuresis and natri-and kaliuresis, decreased systolic and diastolic pressures in the pulmonary artery. The incidence of adverse reactions and the causes of their occurrence are analyzed.
对两种药物进行了比较评估,其中一种是苏联的β-甲基地高辛(medixin),另一种是国外类似物(南斯拉夫LEK公司生产的)贝美可(digicor)。在81例不同心力衰竭阶段的患者中发现这两种药物具有同等的高临床疗效(85%)。积极的治疗效果伴随着心率降低、利尿和尿钠及尿钾排泄增加、肺动脉收缩压和舒张压降低。分析了不良反应的发生率及其发生原因。