Department of Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Department of Cell and Developmental Biology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA; Department of Neurology, University of Michigan School of Medicine, Ann Arbor, MI 48109, USA.
Neuron. 2016 Mar 2;89(5):881-4. doi: 10.1016/j.neuron.2016.02.022.
In this issue, Chandran et al. (2016) pursue a multi-level bioinformatics approach combined with wet bench validation to identify gene networks associated with the regenerative state of injured adult sensory neurons. A small molecular compound, ambroxol, mimics aspects of the identified gene expression patterns and promotes axon regeneration in the injured adult mouse CNS, demonstrating feasibility of in silico-based methods to identify compounds that promote neuronal growth following CNS injury.
在本期中，Chandran 等人（2016 年）采用了一种多层次的生物信息学方法，并结合湿实验验证，以鉴定与受伤成年感觉神经元再生状态相关的基因网络。一种小分子化合物氨溴索模拟了所鉴定的基因表达模式的某些方面，并促进了受伤成年小鼠中枢神经系统中的轴突再生，这证明了基于计算机的方法在鉴定中枢神经系统损伤后促进神经元生长的化合物方面是可行的。
