来自尿路致病性大肠杆菌的含TIR蛋白C对Toll样受体破坏机制的比较分析
A Comparative Analysis of the Mechanism of Toll-Like Receptor-Disruption by TIR-Containing Protein C from Uropathogenic Escherichia coli.
作者信息
Waldhuber Anna, Snyder Greg A, Römmler Franziska, Cirl Christine, Müller Tina, Xiao Tsan Sam, Svanborg Catharina, Miethke Thomas
机构信息
Institut für Medizinische Mikrobiologie, Immunologie und Hygiene, Technische Universität München, Trogerstr. 30, München 81675, Germany.
Institute of Human Virology, Departments of Medicine, and Microbiology and Immunology, University of Maryland, School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, USA.
出版信息
Pathogens. 2016 Feb 29;5(1):25. doi: 10.3390/pathogens5010025.
The TIR-containing protein C (TcpC) of uropathogenic Escherichia coli strains is a powerful virulence factor by impairing the signaling cascade of Toll-like receptors (TLRs). Several other bacterial pathogens like Salmonella, Yersinia, Staphylococcus aureus but also non-pathogens express similar proteins. We discuss here the pathogenic potential of TcpC and its interaction with TLRs and TLR-adapter proteins on the molecular level and compare its activity with the activity of other bacterial TIR-containing proteins. Finally, we analyze and compare the structure of bacterial TIR-domains with the TIR-domains of TLRs and TLR-adapters.
尿路致病性大肠杆菌菌株中含TIR的蛋白C（TcpC）是一种强大的毒力因子，可损害Toll样受体（TLR）的信号级联反应。其他几种细菌病原体，如沙门氏菌、耶尔森氏菌、金黄色葡萄球菌以及一些非病原体也表达类似蛋白。我们在此讨论TcpC的致病潜力及其在分子水平上与TLR和TLR衔接蛋白的相互作用，并将其活性与其他含细菌TIR蛋白的活性进行比较。最后，我们分析并比较细菌TIR结构域与TLR和TLR衔接蛋白的TIR结构域。
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