Chisari F V
Research Institute of Scripps Clinic, La Jolla, CA 92037.
Mol Biol Med. 1989 Apr;6(2):143-9.
In order to study aspects of the biology and pathogenesis of the hepatitis B virus (HBV), not readily approachable by existing tissue culture systems and animal models, several groups have introduced the HBV genome and subgenomic fragments into the germ line of transgenic mice. Substantial new information has been forthcoming from these studies in several areas including tissue-specific expression, hormonal regulation, sex influences, viral replication and disease pathogenesis. These developments are reviewed in the context of the genetic organization and functional properties of the virus and its gene products, and their implications with respect to HBV biology and pathogenesis are discussed.
为了研究乙型肝炎病毒（HBV）生物学和发病机制中现有组织培养系统和动物模型难以触及的方面，多个研究小组已将HBV基因组和亚基因组片段导入转基因小鼠的种系。这些研究在包括组织特异性表达、激素调节、性别影响、病毒复制和疾病发病机制等多个领域带来了大量新信息。本文结合病毒及其基因产物的遗传组织和功能特性对这些进展进行综述，并讨论它们对HBV生物学和发病机制的影响。
