Prog Drug Res. 2016;71:145-9.
The diabetes-inducing agent streptozotocin (STZ) is a glucosamine-nitrosourea compound produced by Streptomyces achromogenes, which specifically induces DNA strand breakage in β-cells causing diabetes mellitus. The destruction of pancreatic β-cells by STZ is associated with a huge release of insulin in their first phase, and then in the second phase, the destruction has lead to deficiency of insulin causes hyperglycaemia. A detailed method on selection of diabetic animals, investigation of blood glucose levels, body weight, biochemical and histopathological parameters is presented in this chapter.
致糖尿病药物链脲佐菌素（STZ）是一种由无色链霉菌产生的葡糖胺-亚硝基脲化合物，它能特异性地诱导β细胞中的DNA链断裂，从而引发糖尿病。STZ对胰腺β细胞的破坏在第一阶段伴随着胰岛素的大量释放，而在第二阶段，这种破坏导致胰岛素缺乏，进而引起高血糖症。本章介绍了选择糖尿病动物、检测血糖水平、体重、生化和组织病理学参数的详细方法。
