Olteanu Horatiu
Department of Pathology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA.
Surg Pathol Clin. 2016 Mar;9(1):101-16. doi: 10.1016/j.path.2015.09.009.
This article provides an overview of the role of flow cytometry in the diagnosis and follow-up of plasma cell myeloma. A brief introduction to the general immunophenotypic features of normal and myeloma plasma cells is provided, followed by a discussion of technical issues as they relate to the application of flow cytometry in this entity. The prognostic and therapeutic utility of flow cytometric immunophenotyping in myeloma is also analyzed, with an emphasis on the growing role of minimal residual analysis as potential biomarker for evaluating treatment efficacy and for tailoring risk-adapted treatment, in prospective clinical trials.
本文概述了流式细胞术在浆细胞骨髓瘤诊断及随访中的作用。文中简要介绍了正常浆细胞和骨髓瘤浆细胞的一般免疫表型特征，随后讨论了与流式细胞术在该疾病中的应用相关的技术问题。还分析了流式细胞术免疫表型分析在骨髓瘤中的预后和治疗效用，重点强调了微小残留病分析在评估治疗疗效和制定风险适应性治疗方案方面日益增长的作用，这是在前瞻性临床试验中的潜在生物标志物。
