Belousov L V
Ontogenez. 1989 Nov-Dec;20(6):626-36.
Since morphogenetic processes are nonlinear, feedback must be essential for their regulation. Two concepts of feedback in morphogenesis are developed: 1) inhibition by diffusing morphogenetic substances and 2) action of mechanical strain resulting from morphogenetic movements. The data on the role of mechanical strain in formation of integral structure of embryonic tissues, primary demarcation of embryonic epithelia and mesenchymal rudiments and bending of epithelial layers are presented. Evolutionary aspects of morphogenetic role of mechanical strain and its possible use in applied biotechnology are discussed.
由于形态发生过程是非线性的，反馈对于其调节必定至关重要。本文提出了形态发生中反馈的两个概念：1）扩散的形态发生物质的抑制作用，以及2）形态发生运动产生的机械应变的作用。文中呈现了关于机械应变在胚胎组织整体结构形成、胚胎上皮和间充质原基的初步分界以及上皮层弯曲中所起作用的数据。还讨论了机械应变形态发生作用的进化方面及其在应用生物技术中的可能用途。
