神经元发育中的膜运输：神经连接的来与去
Membrane Trafficking in Neuronal Development: Ins and Outs of Neural Connectivity.
作者信息
Winkle Cortney Chelise, Gupton Stephanie L
机构信息
Neuroscience Center and Curriculum in Neurobiology, University of North Carolina, Chapel Hill, NC, United States of America.
Neuroscience Center and Curriculum in Neurobiology, University of North Carolina, Chapel Hill, NC, United States of America; Department of Cell Biology and Physiology, University of North Carolina, Chapel Hill, NC, United States of America; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, United States of America.
出版信息
Int Rev Cell Mol Biol. 2016;322:247-80. doi: 10.1016/bs.ircmb.2015.10.003. Epub 2016 Jan 6.
Abstract
During development, neurons progress through rapid yet stereotypical shape changes to achieve proper neuronal connectivity. This morphological progression requires carefully orchestrated plasma membrane expansion, insertion of membrane components including receptors for extracellular cues into the plasma membrane and removal and trafficking of membrane materials and proteins to specific locations. This review outlines the cellular machinery of membrane trafficking that play an integral role in neuronal cell shape change and function from initial neurite formation to pathway navigation and synaptogenesis.
摘要
在发育过程中，神经元经历快速但刻板的形态变化以实现适当的神经元连接。这种形态学进展需要精心协调的质膜扩张、将包括细胞外信号受体在内的膜成分插入质膜以及将膜材料和蛋白质去除并运输到特定位置。本综述概述了膜运输的细胞机制，这些机制在神经元细胞形态变化和功能中起着不可或缺的作用，从最初的神经突形成到通路导航和突触发生。
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