Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev str., Bld. 9, 1113 Sofia, Bulgaria.
Gebze Technical University, Department of Chemistry, P. O. Box 141, Gebze-Kocaeli 41400, Turkey.
Photodiagnosis Photodyn Ther. 2016 Jun;14:98-103. doi: 10.1016/j.pdpdt.2016.02.008. Epub 2016 Mar 3.
The development of new water-soluble photosensitizers for photodynamic therapy (PDT) applications is a very active research topic. Efforts have been made to obtain the far-red absorbing phthalocyanine complexes with molecular design that facilitates the uptake and selectivity for a high PDT efficiency.
The monomolecular lutetium(III) acetate phthalocyanines (LuPcs) substituted with methylpyridyloxy groups at non-peripheral (5) and peripheral (6) positions were synthesized by following the modification of the well-known synthetical routes. The photo-physicochemical properties of the both quaternized LuPcs were evaluated by the steady-state and time-resolved spectroscopy. The photochemical technique was applied to study the generation of the singlet oxygen.
Two water-soluble and cationic LuPcs were synthesized and chemically characterized. The photo-physicochemical properties of absorption (675 and 685nm) and the red shifted fluorescence (704 and 721nm) as well as the fluorescence lifetimes (2.24 and 3.27ns) were studied. The promising values of singlet oxygen quantum yields (0.32 for 5 and 0.35 for 6) were determined.
Lutetium(III) acetate phthalocyanine complexes were synthesized and evaluated with physicochemical properties suitable for future photodynamic therapy applications.
开发新的用于光动力疗法（PDT）应用的水溶性光敏剂是一个非常活跃的研究课题。人们努力获得具有分子设计的远红吸收酞菁配合物，以促进摄取并具有高 PDT 效率的选择性。
通过对众所周知的合成路线进行修改，合成了取代有甲基吡啶氧基的单核镥（III）乙酸酞菁（LuPc），取代位置分别为非外围（5）和外围（6）。通过稳态和时间分辨光谱评估了这两种季铵化 LuPc 的光物理化学性质。光化学技术用于研究单线态氧的生成。
合成并化学表征了两种水溶性和阳离子型 LuPc。研究了吸收（675nm 和 685nm）和红移荧光（704nm 和 721nm）以及荧光寿命（2.24ns 和 3.27ns）的光物理化学性质。确定了具有前途的单线态氧量子产率（5 为 0.32，6 为 0.35）。
合成了镥（III）乙酸酞菁配合物，并评估了其适合未来光动力疗法应用的物理化学性质。
