Razavi Ratki Seyed Kazem, Seyedhosseini Seyedmostafa, Valizadeh Alieh, Rastgoo Tahere, Tavakkoli Rozita, Golabchi Allahyar, Ghashghaei Fatemeh Esteki, Nemayandeh Seyede Mahdieh, Boroomand Amirreza, Shirinzade Atefeh
Department of Radiology, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, I.R. Iran.
Department of Cardiology, Cardiac Electrophysiology Center, Afshar Hospital, Shahid Sadooghi University of Medical Sciences, Yazd, Iran.
Int J Prev Med. 2016 Jan 25;7:26. doi: 10.4103/2008-7802.174891. eCollection 2016.
High blood pressure (BP) has been known as a major risk factor for many chronic diseases. It should be noted, a psychiatric disorder which is common in the people living modern lifestyle may be one of the leading causes of hypertension, and many people are prescribed antidepressant each year. Hence, the purpose of this study was to evaluate the effect of selective serotonin reuptake inhibitors (SSRIs) and alprazolam which defined as antidepressant on the BP levels, and to compare the BP levels between the group of users and nonusers.
This randomized clinical trial study was conducted at the Nohom Dey Hospital in the Torbat-e Heydarieh, Iran between December 2011 and March 2012. Participants comprised 101 psychiatric patients with hypertension that randomly separated into users and nonusers of antidepressant. The period of intervention lasted for 3 months. The mean of BP calculated by this formula (systolic BP [SBP] +2 diastolic BP [DBP])/3 which was the main outcome of the study.
Users of antidepressant drugs did not have any significant changes in BP levels, except in patients who received SSRIs alone, significant improvement was observed in DBP (P = 0.04) and mean of BP (P = 0.03). While, in nonusers of antidepressant, significant development was observed in DBP, and mean of BP. Comparing the users and nonusers did not show any significant differences in SBP, DBP, and Mean of BP; even, when outcomes were adjusted for risk factors and antihypertensive drugs.
Three months treatment with SSRIs and alprazolam did not have any effect on lowering BP level in patients with the psychiatric disorder.
高血压一直被认为是许多慢性疾病的主要危险因素。应当指出的是，一种在现代生活方式人群中常见的精神疾病可能是高血压的主要病因之一，并且每年有许多人被开抗抑郁药。因此，本研究的目的是评估被定义为抗抑郁药的选择性5-羟色胺再摄取抑制剂（SSRIs）和阿普唑仑对血压水平的影响，并比较使用者和非使用者之间的血压水平。
这项随机临床试验研究于2011年12月至2012年3月在伊朗托尔巴特海达里耶的诺洪代伊医院进行。参与者包括101名患有高血压的精神疾病患者，他们被随机分为抗抑郁药使用者和非使用者。干预期持续3个月。通过该公式（收缩压[SBP]+2×舒张压[DBP]）/3计算血压平均值，这是研究的主要结果。
抗抑郁药使用者的血压水平没有任何显著变化，除了单独接受SSRIs的患者，舒张压（P = 0.04）和血压平均值（P = 0.03）有显著改善。而在抗抑郁药非使用者中，舒张压和血压平均值有显著变化。比较使用者和非使用者在收缩压、舒张压和血压平均值方面没有显示出任何显著差异；甚至在对危险因素和抗高血压药物进行结果调整时也是如此。
用SSRIs和阿普唑仑进行三个月治疗对患有精神疾病的患者降低血压水平没有任何效果。
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