利用线粒体作为依赖膜电位的化学反应室。
Exploiting Mitochondria In Vivo as Chemical Reaction Chambers Dependent on Membrane Potential.
机构信息
Buck Institute for Research on Aging, Novato, CA 94945, USA.
出版信息
Mol Cell. 2016 Mar 3;61(5):642-643. doi: 10.1016/j.molcel.2016.02.026.
PMID:26942666
Abstract
Recently in Cell Metabolism, Logan et al. (2016) exploit membrane potential-dependent mitochondrial accumulation of charged precursors, causing them to combine by "click" chemistry 1,000,000 times faster than without accumulation to generate an ultrasensitive indicator for membrane potentials and foreshadow targeted drug synthesis in vivo.
摘要
最近，在《细胞代谢》杂志上，Logan 等人（2016 年）利用膜电位依赖的带电荷前体在线粒体中的积累，使它们通过“点击”化学反应结合的速度比没有积累时快 100 万倍，从而生成了一种超灵敏的膜电位指示剂，并预示着体内靶向药物合成的前景。
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