Hermsen A M, Haag A, Duddek C, Balkenhol K, Bugiel H, Bauer S, Mylius V, Menzler K, Rosenow F
Epilepsy Center Hessen, Department of Neurology, Philipps-University Marburg, Germany; Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Neurocenter, J.W. Goethe University, Frankfurt am Main, Germany.
Epilepsy Center Hessen, Department of Neurology, Philipps-University Marburg, Germany.
J Neurol Sci. 2016 Mar 15;362:209-16. doi: 10.1016/j.jns.2016.01.039. Epub 2016 Jan 22.
To determine the influence of different factors on test-retest reliability of frequently used transcranial magnetic stimulation (TMS) parameters while controlling for potential confounders in healthy subjects.
TMS was applied in 93 healthy volunteers (61% male) twice (mean retest interval of 34.0 ± 25.6 (SD) days) between 7 am and 2 pm by four investigators (sessions n investigator A=47, investigator B=95, investigator C=28, investigator D=16). Women were assessed in their follicular phase. Test stimulus (TS), resting motor threshold (RMT), short latency intracortical inhibition (SICI), intracortical facilitation (ICF) and cortical silent period (SCP) were analyzed.
Good test-retest reliabilities were observed for TS (r=.880) and RMT (r=.826), moderate for visual and automated analyzed CSP durations (resp. r=.466, r=.486), and poor for ICF (r=-.159). Reliable change indexes are reported. Gender (e.g. automated CSP women: r=.538 vs. men: r=.422), re-test interval and method of CSP-analysis did not influence reliabilities.
In a large sample of healthy volunteers we found good to moderate test-retest reliabilities in all but one TMS-parameter. Automated analysis of the CSP did not prove to be more reliable than visual determination.
This study contains analyses of re-test reliability in TMS considering several confounding factors. For the first time it presents reliable change indices for all frequently used TMS parameters.
在控制健康受试者潜在混杂因素的情况下，确定不同因素对常用经颅磁刺激（TMS）参数重测信度的影响。
93名健康志愿者（61%为男性）于上午7点至下午2点之间接受了4名研究人员进行的两次TMS治疗（平均重测间隔为34.0±25.6（标准差）天）（研究人员A治疗47例，研究人员B治疗95例，研究人员C治疗28例，研究人员D治疗16例）。女性在卵泡期接受评估。分析了测试刺激（TS）、静息运动阈值（RMT）、短潜伏期皮质内抑制（SICI）、皮质内易化（ICF）和皮质静息期（SCP）。
TS（r = 0.880）和RMT（r = 0.826）的重测信度良好，视觉和自动分析的CSP持续时间的重测信度中等（分别为r = 0.466，r = 0.486），ICF的重测信度较差（r = -0.159）。报告了可靠变化指数。性别（如自动分析的CSP女性：r = 0.538，男性：r = 0.422）、重测间隔和CSP分析方法不影响信度。
在一大群健康志愿者中，我们发现除一个TMS参数外，所有参数的重测信度良好至中等。CSP的自动分析并不比视觉测定更可靠。
本研究包含了考虑多个混杂因素的TMS重测信度分析。首次给出了所有常用TMS参数的可靠变化指数。
