Asayama Y, Nishie A, Ishigami K, Ushijima Y, Takayama Y, Okamoto D, Fujita N, Morita K, Obara M, Honda H
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Clin Radiol. 2016 May;71(5):432-7. doi: 10.1016/j.crad.2016.01.023. Epub 2016 Mar 2.
To clarify whether the heterogeneity of non-cancerous liver parenchyma (NLP) in the hepatobiliary phase on gadoxetic acid enhanced magnetic resonance imaging (MRI) is correlated with hepatocellular carcinoma (HCC) development.
Institutional review board approval was obtained, and the requirements for informed consent were waived for this retrospective study. The imaging characteristics of 84 patients with chronic liver disease who underwent gadoxetic acid-enhanced 3T MRI between January 2013 and October 2014 were examined retrospectively. For the evaluation of the heterogeneity of the intensity in the hepatobiliary phase, the largest possible region of interest was placed on the NLP, and the skewness and kurtosis were calculated using ImageJ software. Skewness is the degree of asymmetry of a histogram, and kurtosis is a measure of the peak. Based on the median values of kurtosis and skewness, the patients were classified into four categories and the categories were compared between the 49 patients with HCC (HCC group) and the 35 patients without HCC (non-HCC group).
Kurtosis was significantly higher in the HCC group compared to the non-HCC group (1.19±1.15 versus 0.43±0.83; p=0.0006). Skewness was significantly lower in the HCC group than in the non-HCC group (1.19±1.15 versus 0.43±0.83; p=0.0152). In a multivariate logistic analysis, the category showing lower-than-the-median (-0.1185) skewness and higher-than-the-median (0.547) kurtosis was significantly and independently associated with HCC development (p=0.0031).
The heterogeneity of NLP in the hepatobiliary phase on gadoxetic acid enhanced MRI may reflect the development of HCC.
明确钆塞酸增强磁共振成像（MRI）肝胆期非癌性肝实质（NLP）的异质性是否与肝细胞癌（HCC）的发生相关。
本回顾性研究获得了机构审查委员会的批准，并豁免了知情同意的要求。回顾性分析了2013年1月至2014年10月期间接受钆塞酸增强3T MRI检查的84例慢性肝病患者的影像特征。为评估肝胆期信号强度的异质性，在NLP上放置尽可能大的感兴趣区，并使用ImageJ软件计算偏度和峰度。偏度是直方图不对称程度的度量，峰度是峰值的度量。根据峰度和偏度的中位数，将患者分为四类，并比较49例HCC患者（HCC组）和35例无HCC患者（非HCC组）之间的类别。
HCC组的峰度显著高于非HCC组（1.19±1.15对0.43±0.83；p = 0.0006）。HCC组的偏度显著低于非HCC组（1.19±1.15对0.43±0.83；p = 0.0152）。在多因素逻辑分析中，显示低于中位数（-0.1185）偏度和高于中位数（0.547）峰度的类别与HCC发生显著且独立相关（p = 0.0031）。
钆塞酸增强MRI肝胆期NLP的异质性可能反映HCC的发生。
