Antonova A I, Vasilenko I V
Vestn Oftalmol. 1989 Nov-Dec;105(6):7-10.
The authors analyze the findings of histomorphologic and immunomorphologic studies of 20 cadaver optic nerves from subjects with a history of acute vascular optic neuropathies due to atherosclerosis, eventuating in optic nerve atrophy: 13 atrophic optic nerves and 7 pair nerves from clinically normal eyes of the same patients were examined. The blood sera of 30 patients suffering from acute vascular optic neuropathies were tested. Noteworthy that vascular optic neuropathy associated with atherosclerosis is a bilateral process. Vascular insufficiency due to sclerotic changes in vessels of various diameters undoubtedly contributes to the pathogenesis of the optic nerve impairments in the involved and clinically healthy eyes. The developing immune status disorders and autoimmune processes also contribute to the genesis of sclerotic shifts in the vessels and optic nerve atrophy in both eyes.
作者分析了20例因动脉粥样硬化导致急性血管性视神经病变并最终导致视神经萎缩患者的尸体视神经的组织形态学和免疫形态学研究结果：检查了13条萎缩的视神经以及来自同一患者临床正常眼睛的7对神经。对30例患有急性血管性视神经病变的患者的血清进行了检测。值得注意的是，与动脉粥样硬化相关的血管性视神经病变是一个双侧过程。不同直径血管的硬化改变导致的血管功能不全无疑是受累眼和临床健康眼视神经损伤发病机制的一个因素。免疫状态紊乱和自身免疫过程的发展也促成了双眼血管硬化改变和视神经萎缩的发生。
