Mouzakis Dionysios, Zaoutsos Stefanos Polymeros, Bouropoulos Nikolaos, Rokidi Stamatia, Papanicolaou George
Department of Mechanical Engineering, Technological Educational Institute of Thessaly, Larissa, Greece.
Department of Mechanical Engineering, Technological Educational Institute of Thessaly, Larissa, Greece
J Biomater Appl. 2016 Jul;31(1):112-20. doi: 10.1177/0885328216636762. Epub 2016 Mar 4.
The biological and mechanical nature of calcium phosphate cements (CPC's) matches well with that of bone tissues, thus they can be considered as an appropriate environment for bone repair as bone defect fillers. The current study focuses on the experimental characterization of the mechanical properties of CPCs that are favorably used in clinical applications. Aiming on evaluation of their mechanical performance, tests in compression loading were conducted in order to determine the mechanical properties of the material under study. In this context, experimental results occurring from the above mechanical tests on porous specimens that were fabricated from three different porous additives, namely albumin, gelatin and sodium alginate, are provided, while assessment of their mechanical properties in respect to the used porous media is performed. Additionally, samples reinforced with hydroxyapatite crystals were also tested in compression and the results are compared with those of the above tested porous CPCs. The knowledge obtained allows the improvement of their biomechanical properties by controlling their structure in a micro level, and finds a way to compromise between mechanical and biological response.
磷酸钙骨水泥（CPC）的生物学和力学性质与骨组织的性质非常匹配，因此它们可被视为作为骨缺损填充剂用于骨修复的合适环境。当前的研究集中在临床应用中常用的CPC力学性能的实验表征。为了评估其力学性能，进行了压缩加载测试以确定所研究材料的力学性能。在此背景下，提供了对由三种不同的多孔添加剂（即白蛋白、明胶和海藻酸钠）制成的多孔试样进行上述力学测试所得到的实验结果，同时对其相对于所用多孔介质的力学性能进行了评估。此外，还对用羟基磷灰石晶体增强的样品进行了压缩测试，并将结果与上述测试的多孔CPC的结果进行了比较。所获得的知识有助于通过在微观层面控制其结构来改善其生物力学性能，并找到一种在力学和生物学反应之间取得平衡的方法。
