Silva Anielle Christine Almeida, Freschi Ana Paula Peres, Rodrigues Cláudia Mendonça, Matias Bruna França, Maia Larissa Prado, Goulart Luiz Ricardo, Dantas Noelio Oliveira
Laboratório de Novos Materiais Isolantes e Semicondutores (LNMIS), Physics Institute, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
Laboratório de Novos Materiais Isolantes e Semicondutores (LNMIS), Physics Institute, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil; Laboratório de Nanobiotecnologia, Institute of Genetics and Biochemistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, Brazil.
Nanomedicine. 2016 Jul;12(5):1421-30. doi: 10.1016/j.nano.2016.01.001. Epub 2016 Mar 3.
Although colloidal magic-sized quantum dots present great promise for biological applications due to their high stability and strong luminescence, nanotoxicological analyses are scarcely reported and biomedical applications have not been demonstrated. This is the first report on biological effects of CdSe/CdSxSe1-x/CdS core-shell magic-sized quantum dot (CS-MSQD) with specific application in breast cancer cell detection. The 2-nm CS-MSQD presents a broad bandwidth emission from 450 to 750nm, low toxicity, non-immunogenicity and biocompatibility. The CS-MSQD was conjugated to a breast cancer-specific Fab antibody, and passively diffused into cells for in vitro detection of a breast cancer cell line, demonstrating to be an unprecedented tool for biomedical applications.
尽管胶体魔法尺寸量子点因其高稳定性和强发光性在生物应用方面展现出巨大潜力，但纳米毒理学分析报道极少，生物医学应用也尚未得到证实。这是关于CdSe/CdSxSe1-x/CdS核壳魔法尺寸量子点（CS-MSQD）对乳腺癌细胞检测的特定应用所产生生物效应的首次报道。2纳米的CS-MSQD呈现出450至750纳米的宽带发射、低毒性、非免疫原性和生物相容性。CS-MSQD与乳腺癌特异性Fab抗体偶联，并被动扩散进入细胞以用于体外检测乳腺癌细胞系，证明其是生物医学应用中前所未有的工具。
