Schulzke J D, Riecken E O
Abteilung für Innere Medizin mit Schwerpunkt Gastroenterologie, Universitätsklinikum Steglitz, Freie Universität Berlin.
Z Gastroenterol. 1989 Nov;27(11):693-700.
First, general principles of epithelial transport and the epithelial barrier function are described. The cellular mechanisms of Na-glucose cotransport, electrogenic Cl-secretion, and electrogenic Na-absorption are presented. Second, the pathophysiology of epithelial transport systems and their regulation is given as far as relevant for the onset of diarrhea. This includes congenital deficiency of transport proteins and mucosal transformation as e.g. during celiac disease, tropical sprue, and the blind loop syndrome. Finally, regulation of epithelial transport by the enteric nervous system, GI-peptides, hormones, and the intestinal immune system is discussed in respect to disturbances of this regulation as for example seen in the presence of bacterial enterotoxins.
首先，描述上皮运输的一般原理和上皮屏障功能。介绍了钠-葡萄糖共转运、电致氯分泌和电致钠吸收的细胞机制。其次，就腹泻的发病机制而言，给出了上皮运输系统的病理生理学及其调节。这包括转运蛋白的先天性缺陷和黏膜转化，如在乳糜泻、热带口炎性腹泻和盲袢综合征期间。最后，针对肠道神经系统、胃肠肽、激素和肠道免疫系统对上皮运输的调节，讨论了这种调节的紊乱情况，例如在存在细菌肠毒素时所见到的情况。
