Gavva Chakri, Sarode Ravindra, Agrawal Deepak, Burner James
Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9072, USA.
Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390-9030, USA.
Transfus Apher Sci. 2016 Feb;54(1):99-102. doi: 10.1016/j.transci.2016.02.001. Epub 2016 Feb 20.
Acute hypertriglyceridemia induced pancreatitis (HTP) presents with a more severe clinical course compared to other etiologies of pancreatitis. Therapeutic plasma exchange (TPE) is a potential treatment option for lowering plasma triglycerides and possibly decreasing morbidity and mortality. However, clinical data regarding its effectiveness are limited.
We retrospectively examined the clinical data and outcomes of 13 consecutive episodes of HTP in which TPE was employed to reduce plasma triglycerides during a 15-month period.
The TPE was initiated at a median of 19 hours from the time of presentation. We performed 1.2-1.5 volume TPEs with 5% albumin as the replacement fluid. After only one TPE procedure, the mean plasma triglycerides values decreased from 2993 mg/dl to 487 mg/dl with a reduction of 84%. All 13 patients survived with a mean length of hospital stay of 9.5 days. There were no complications related to TPE.
One TPE procedure is an effective method for reducing plasma triglycerides and possibly decreases the length of hospital stay in patients admitted with HTP.
与其他病因引起的胰腺炎相比，急性高甘油三酯血症性胰腺炎（HTP）的临床病程更为严重。治疗性血浆置换（TPE）是降低血浆甘油三酯并可能降低发病率和死亡率的一种潜在治疗选择。然而，关于其有效性的临床数据有限。
我们回顾性研究了15个月期间连续13例采用TPE降低血浆甘油三酯的HTP患者的临床资料和结局。
TPE在就诊后中位时间19小时开始。我们使用5%白蛋白作为置换液进行1.2 - 1.5个血浆容量的TPE。仅经过一次TPE治疗后，平均血浆甘油三酯值从2993mg/dl降至487mg/dl，降低了84%。所有13例患者均存活，平均住院时间为9.5天。没有与TPE相关的并发症。
一次TPE治疗是降低HTP患者血浆甘油三酯的有效方法，并可能缩短其住院时间。
