He Y-F, Luo H-Q, Wang W, Chen J, Yao Y-W, Yan Y, Wu S-S, Hu X-X, Ke L-H, Niu J-Y, Li H-M, Ji C-S, Hu B
Department of Medical Oncology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui, China.
Department of Medical Oncology, Anhui Provincial Cancer Hospital, Hefei, Anhui, China.
Eur J Cancer Care (Engl). 2017 Mar;26(2). doi: 10.1111/ecc.12445. Epub 2016 Mar 7.
Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) had been analysed in many kind of tumours, but its role of predict the oesophageal squamous cell carcinoma (ESCC) patients' prognosis was not reach a consensus. Relationship between NLR, PLR and ESCC located in the middle or lower segment was evaluated. 317 patients with ESCC who underwent attempted curative oesophagectomy were analysed in this study. 157 and 98 patients had elevated NLR and PLR respectively (NLR >3.3 and PLR >150). The median overall survival time (OS) and disease-free survival (DFS) was 34.1 and 19.2 months respectively. Multivariate analysis found PLR >150 (P = 0.018, HR 1.426, 95%CI 1.063-1.912) accompanied by male, lymphatic metastases, tumour size more than 3 cm, tumour located at middle segment and poor differentiation were associated with significantly worse DFS. Meanwhile, gender, lymphatic metastases, tumour location and differentiation along with PLR >150 (P = 0.003, HR 1.595, 95% CI 1.172-2.170) and NLR>3.3 (P = 0.039, HR 1.367, 95% CI 1.015-1.840) were all independent prognostic factors for OS. Preoperative NLR and PLR might be used as predictive factors in patients with ESCC. For DFS, elevated PLR compared to NLR may have an advantage to indicate poor prognosis.
中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）已在多种肿瘤中进行了分析，但其在预测食管鳞状细胞癌（ESCC）患者预后方面的作用尚未达成共识。本研究评估了NLR、PLR与中下段ESCC之间的关系。本研究分析了317例行根治性食管切除术的ESCC患者。分别有157例和98例患者的NLR和PLR升高（NLR>3.3且PLR>150）。中位总生存时间（OS）和无病生存时间（DFS）分别为34.1个月和19.2个月。多因素分析发现，PLR>150（P=0.018，HR 1.426，95%CI 1.063-1.912），同时伴有男性、淋巴转移、肿瘤大小超过3 cm、肿瘤位于中段以及低分化，与DFS显著较差相关。同时，性别、淋巴转移、肿瘤位置和分化程度，以及PLR>150（P=0.003，HR 1.595，95%CI 1.172-2.170）和NLR>3.3（P=0.039，HR 1.367，95%CI 1.015-1.840）均为OS的独立预后因素。术前NLR和PLR可作为ESCC患者的预测因素。对于DFS，与NLR相比，PLR升高可能更有利于提示预后不良。
