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环化和不饱和作用而非侧链的异构化决定了阳离子两亲性聚合物的选择性抗菌活性。

Cyclization and unsaturation rather than isomerisation of side chains govern the selective antibacterial activity of cationic-amphiphilic polymers.

作者信息

Uppu D S S M, Bhowmik M, Samaddar S, Haldar J

机构信息

Chemical Biology and Medicinal Chemistry Laboratory, New Chemistry Unit, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Jakkur, Bangalore, India-560064.

出版信息

Chem Commun (Camb). 2016 Mar 28;52(25):4644-7. doi: 10.1039/c5cc09930g.

DOI:10.1039/c5cc09930g
PMID:26947459
Abstract

Membrane-active agents represent a promising alternative to overcome antibiotic resistance. Here, we report cationic-amphiphilic polymers with variations in the side chain architecture such as cyclization, isomerization and unsaturation that resulted in potent antibacterial activity and low mammalian cell toxicity with a membrane-active mode of action.

摘要

膜活性剂是克服抗生素耐药性的一种有前景的替代方法。在此，我们报道了侧链结构存在环化、异构化和不饱和等变化的阳离子两亲聚合物，这些聚合物具有强大的抗菌活性、对哺乳动物细胞毒性低以及膜活性作用模式。

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