日本2型糖尿病患者的血清脂蛋白（a）水平与糖尿病肾病
Serum lipoprotein(a) levels and diabetic nephropathy among Japanese patients with type 2 diabetes mellitus.
作者信息
Senba Hidenori, Furukawa Shinya, Sakai Takenori, Niiya Tetsuji, Miyake Teruki, Yamamoto Shin, Ueda Teruhisa, Torisu Masamoto, Minami Hisaka, Miyaoka Hiroaki, Onji Morikazu, Tanaka Keiko, Matsuura Bunzo, Tanigawa Takeshi, Hiasa Yoichi, Miyake Yoshihiro
机构信息
Department of Epidemiology and Preventive Medicine, Ehime University GraduateSchool of Medicine, Toon, Ehime, Japan.
Department of Epidemiology and Preventive Medicine, Ehime University GraduateSchool of Medicine, Toon, Ehime, Japan; Epidemiology and Medical Statistics Unit, Translational Research Center, Ehime University Hospital, Toon, Ehime, Japan.
出版信息
J Diabetes Complications. 2016 Jul;30(5):923-7. doi: 10.1016/j.jdiacomp.2016.02.006. Epub 2016 Feb 12.
AIMS
We aimed to evaluate the association between serum lipoprotein(a) [Lp(a)] levels and diabetic nephropathy among Japanese patients with type 2 diabetes mellitus.
METHODS
This study included 581 patients with type 2 diabetes mellitus. Serum Lp(a) levels were divided into four groups; the cut-off points were at the 30th, 60th, and 90th percentile values on the basis of the distribution for all subjects. Diabetic nephropathy was defined as present when the urinary albumin-creatinine ratio was ≥33.9mg/mmol creatinine and/or the estimated glomerular filtration rate was <30ml/min/1.72m(2). Adjustment was made for age, sex, body mass index, hemoglobin A1c, duration of diabetes mellitus, current drinking, current smoking, hypertension, dyslipidemia, coronary heart disease, and stroke.
RESULTS
Higher serum Lp(a) levels were significantly associated with a higher prevalence of diabetic nephropathy: the adjusted odds ratios (95% confidence intervals) for diabetic nephropathy in relation to serum Lp(a) levels of ≤6, 7-15, 16-38, and ≥39mg/dl were 1.00 (reference), 2.74 (1.08-7.00), 3.31 (1.28-8.54), and 4.80 (1.57-14.60), respectively (P for trend=0.004).
CONCLUSIONS
The results suggest that serum Lp(a) levels may be positively associated with diabetic nephropathy among Japanese patients with type 2 diabetes mellitus.
目的
我们旨在评估日本2型糖尿病患者血清脂蛋白(a)[Lp(a)]水平与糖尿病肾病之间的关联。
方法
本研究纳入了581例2型糖尿病患者。血清Lp(a)水平分为四组；根据所有受试者的分布情况，切点分别为第30、60和90百分位数。当尿白蛋白肌酐比值≥33.9mg/mmol肌酐和/或估计肾小球滤过率<30ml/min/1.72m²时，定义为患有糖尿病肾病。对年龄、性别、体重指数、糖化血红蛋白、糖尿病病程、当前饮酒情况、当前吸烟情况、高血压、血脂异常、冠心病和中风进行了校正。
结果
较高的血清Lp(a)水平与糖尿病肾病的较高患病率显著相关：血清Lp(a)水平≤6、7-15、16-38和≥39mg/dl时，糖尿病肾病的校正比值比(95%置信区间)分别为1.00(参考值)、2.74(1.08-7.00)、3.31(1.28-8.54)和4.80(1.57-14.60)(趋势P值=0.004)。
结论
结果表明，在日本2型糖尿病患者中，血清Lp(a)水平可能与糖尿病肾病呈正相关。
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