Carrilho F M
Acta Med Port. 1989 Aug-Oct;2(4-5):231-3.
The author reviews the etiopathogeny of autoimmune thyroiditis: sequestered antigen, clonal selection, acquired tolerance with low doses of antigen and disordered immunoregulation. The main thyroid autoantibodies, their characteristics and functions are described. The genetic susceptibility associated to HLA antigen as well as the importance of inappropriate expression in thyroid epithelium are also pointed out. The experimental autoimmune thyroiditis, induced or spontaneous is shown as a model to the study of human autoimmune thyroiditis.
隐蔽抗原、克隆选择、低剂量抗原诱导的获得性耐受以及免疫调节紊乱。描述了主要的甲状腺自身抗体、其特征和功能。还指出了与HLA抗原相关的遗传易感性以及甲状腺上皮细胞中不适当表达的重要性。诱导性或自发性实验性自身免疫性甲状腺炎被视为研究人类自身免疫性甲状腺炎的模型。
