Shi Xinhao, Gu Wei, Zhang Cuiling, Zhao Longyun, Li Li, Peng Weidong, Xian Yuezhong
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, No. 500, Dongchuan Road, Shanghai, 200241, China.
Chemistry. 2016 Apr 11;22(16):5643-8. doi: 10.1002/chem.201505034. Epub 2016 Mar 7.
The development of highly sensitive and selective methods for the detection of lead ion (Pb(2+)) is of great scientific importance. In this work, we develop a new surface-enhanced Raman scattering (SERS)-based sensor for the selective trace measurement of Pb(2+). The SERS-based sensor is assembled from gold nanoparticles (AuNPs) and graphene using cucurbit[7]uril (CB[7]) as a precise molecular glue and a local SERS reporter. Upon the addition of Pb(2+), CB[7] forms stronger complexes with Pb(2+) and desorbs from AuNPs, resulting in a sensitive "turn-off" of SERS signals. This SERS-based assay shows a limit of detection (LOD) of 0.3 nm and a linear detection range from 1 nm to 0.3 μm for Pb(2+). The feasibility of the assay is further demonstrated by probing Pb(2+) in real water samples. This SERS-based analytical method is highly sensitive and selective, and therefore holds promising applications in environmental analysis.
开发用于检测铅离子（Pb(2+)）的高灵敏度和高选择性方法具有重大的科学意义。在这项工作中，我们开发了一种基于表面增强拉曼散射（SERS）的新型传感器，用于选择性痕量测量Pb(2+)。这种基于SERS的传感器由金纳米颗粒（AuNPs）和石墨烯组装而成，使用葫芦[7]脲（CB[7]）作为精确的分子胶水和局部SERS报告分子。加入Pb(2+)后，CB[7]与Pb(2+)形成更强的配合物并从AuNPs上解吸，导致SERS信号灵敏地“关闭”。这种基于SERS的检测方法对Pb(2+)的检测限（LOD）为0.3 nM，线性检测范围为1 nM至0.3 μM。通过探测实际水样中的Pb(2+)进一步证明了该检测方法的可行性。这种基于SERS的分析方法具有高灵敏度和高选择性，因此在环境分析中具有广阔的应用前景。
