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他汀类药物与心肌梗死:类型、剂量和给药时间:有关系吗?

Statins and myocardial infarction: Type, dose, and administration time: Does it matter?

机构信息

Department of Cardiology, Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom.

1st Department of Cardiology, Hippokration Hospital, University of Athens, Athens, Greece.

出版信息

Trends Cardiovasc Med. 2016 Jul;26(5):433-41. doi: 10.1016/j.tcm.2016.01.001. Epub 2016 Jan 20.

Abstract

Patients with ST-elevation myocardial infarction (STEMI) constitute a vulnerable group that demands the careful assessment and application of all the up-to-date clinical and experimental knowledge, with final aim, the improvement of their prognosis. Statins are an indispensable part of the primary and secondary prevention of coronary artery disease (CAD), not only due to their strong hypolipidemic effect, but also due to their numerous pleiotropic properties that play an important role in the treatment of CAD, especially when the more vulnerable group of STEMI patients is addressed. Nevertheless, there are still issues that require further discussion and clarification, such as the type of statin, the dose of the regimen, the administration time, and the treatment duration.

摘要

急性 ST 段抬高型心肌梗死(STEMI)患者属于高危人群,需要仔细评估和应用所有最新的临床和实验知识,最终目的是改善他们的预后。他汀类药物是冠状动脉疾病(CAD)一级和二级预防的不可或缺的一部分,不仅因为它们具有强大的降脂作用,还因为它们具有许多多效性特性,在 CAD 的治疗中发挥着重要作用,尤其是在更脆弱的 STEMI 患者群体中。然而,仍有一些问题需要进一步讨论和澄清,例如他汀类药物的类型、治疗方案的剂量、给药时间和治疗持续时间。

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