Mizutani S, Iwao N, Miyoshi S, Kameoka H, Yano H, Kishimoto T, Sakurai T, Wakatsuki A, Nakamura T, Honda M
Department of Urology, Osaka Rosai Hospital.
Hinyokika Kiyo. 1989 Dec;35(12):2155-61.
Aztreonam (AZT, Azactam) was given to 176 patients with complicated urinary tract infections (UTI), of whom 110 cases satisfied with the "Criteria of UTI Committee for the Evaluation of Drug Efficacy in the UTI (3rd Ed.)", which was modified by adopting the midstream urine data in cases of women. Aztreonam was administered by drip infusion at a daily dose of 1 to 4 grams (mostly 2 grams) for at least five days long. The overall clinical efficacy rate of AZT in the 110 cases with the complicated UTI was 64%, estimated by the criteria cited above. The efficacy rate according to the infection type groupings was 66% for the 38 patients in the 1st group, 33% for the 3 in the 2nd group, 79% for the 19 in the 3rd group, 85% for the 21 in the 4th, 47% for the 19 in the 5th and 42% for the 12 in the 6th group. The disappearance rate of Gram negative bacilli was 87.1%. Especially 15 strains of Pseudomonas aeruginosa were eliminated out of 25 (60%) after AZT administration. Forty-six strains appeared after AZT treatment, 36 (76%) of which were Gram positive cocci. Subjective side effects and abnormal laboratory findings in a total 176 cases were: diarrhea in one, upper abdominal discomfort in one, increases in glutamic pyruvic transaminase in 8, increases in glutamic oxaloacetic transaminase in 5 and eosinophilia in 1. All of these disappeared after termination of the drug. AZT might therefore be a useful and safe antibiotic for the first choice use against complicated UTI.
氨曲南（AZT，阿兹他啶）用于治疗176例复杂性尿路感染患者，其中110例符合“尿路感染药物疗效评估委员会标准（第3版）”，该标准在女性病例中采用了中段尿数据进行了修改。氨曲南通过静脉滴注给药，每日剂量为1至4克（多数为2克），疗程至少5天。根据上述标准评估，110例复杂性尿路感染患者中氨曲南的总体临床有效率为64%。按感染类型分组的有效率分别为：第一组38例患者中为66%，第二组3例中为33%，第三组19例中为79%，第四组21例中为85%，第五组19例中为47%，第六组12例中为42%。革兰氏阴性杆菌的清除率为87.1%。特别是25株铜绿假单胞菌中有15株（60%）在使用氨曲南后被清除。氨曲南治疗后出现46株菌株，其中36株（76%）为革兰氏阳性球菌。176例患者的主观副作用和实验室异常结果如下：腹泻1例，上腹部不适1例，谷丙转氨酶升高8例，谷草转氨酶升高5例，嗜酸性粒细胞增多1例。所有这些在停药后均消失。因此，氨曲南可能是治疗复杂性尿路感染的一种有用且安全的首选抗生素。
