Department of Medicine, Westchester Medical Center and New York Medical College, Valhalla, NY 10595 USA.
Biomark Res. 2016 Mar 3;4:6. doi: 10.1186/s40364-016-0060-9. eCollection 2016.
Cyclin D1 (CCND1) protein overexpression and/or the t(11;14)(q13;q32) translocation are the pathognomonic hallmarks of mantle cell lymphoma (MCL). However, there have been cases that lacked both t(11;14) and cyclin D1 protein but still had a gene expression profile suggesting a diagnosis of MCL. SOX11 expression was detected in most cyclin D1- negative MCL and can serve as a specific biomarker for the diagnosis of this subset of MCL. Lack of SOX11 expression in MCL was associated with an indolent subset and favorable prognosis.
Cyclin D1 (CCND1) 蛋白过表达和/或 t(11;14)(q13;q32) 易位是套细胞淋巴瘤 (MCL) 的特征性标志。然而，有些病例既缺乏 t(11;14)，也缺乏 cyclin D1 蛋白，但仍具有基因表达谱提示 MCL 的诊断。SOX11 在大多数 cyclin D1 阴性的 MCL 中表达，可作为该亚组 MCL 的特异性诊断标志物。MCL 中缺乏 SOX11 表达与惰性亚组和良好预后相关。
