Umukoro Peter E, Fan Tianteng, Zhang Jinming, Cavallari Jennifer M, Fang Shona C, Lu Chensheng, Lin Xihong, Mittleman Murray A, Schmidt Georg, Christiani David C
Department of Environmental Health (Dr Umukoro, Dr Fan, Dr Zhang, Dr Cavallari, Dr Fang, Dr Lu, Dr Christiani); Consulting (Dr Fan), Adheris Health; Department of Epidemiology (Dr Ittleman, Dr Christiani), Department of Biostatistics (Dr Lin), Harvard T.H. Chan School of Public Health, Boston, Mass; Department of Community Medicine and Health Care (Dr Cavallari), University of Connecticut Health Center, Farmington; Cardiovascular Epidemiology Research Unit (Dr Mittleman), Beth Israel Deaconess Medical Center/Harvard Medical School, Boston, Mass; Medical Department (Dr Schmidt), Munich University of Technology; DZHK (German Centre for Cardiovascular Research) Partner site Munich Heart Alliance (Dr Schmidt), Munich, Germany; and Pulmonary and Critical Care Unit (Dr Christiani), Massachusetts General Hospital/Harvard Medical School, Boston.
J Occup Environ Med. 2016 Mar;58(3):227-31. doi: 10.1097/JOM.0000000000000661.
The aim of the study was to clarify whether long-term metal particulates affect cardiac acceleration capacity (AC), deceleration capacity (DC), or both.
We calculated chronic exposure index (CEI) for PM2.5 over the work life of 50 boilermakers and obtained their resting AC and DC. Linear regression was used to assess the associations between CEI PM2.5 exposure and each of AC and DC, controlling for age, acute effects of welding exposure, and diurnal variation.
Mean (standard deviation) CEI for PM2.5 exposure was 1.6 (2.4) mg/m-work years and ranged from 0.001 to 14.6 mg/m-work years. In our fully adjusted models, a 1 mg/m-work year increase in CEI for PM2.5 was associated with a decrease of 1.03 (95% confidence interval: 0.10, 1.96) ms resting AC, and a decrease of 0.67 (95% confidence interval: -0.14, 1.49) ms resting DC.
Long-term metal particulate exposures decrease cardiac accelerations and decelerations.
本研究旨在阐明长期金属颗粒是否会影响心脏加速能力（AC）、减速能力（DC）或两者皆有影响。
我们计算了50名锅炉工工作生涯中PM2.5的慢性暴露指数（CEI），并获取了他们静息时的AC和DC。采用线性回归评估CEI PM2.5暴露与AC和DC之间的关联，并对年龄、焊接暴露的急性影响和昼夜变化进行了控制。
PM2.5暴露的平均（标准差）CEI为1.6（2.4）mg/m-工作年，范围为0.001至14.6 mg/m-工作年。在我们完全调整的模型中，PM2.5的CEI每增加1 mg/m-工作年，静息AC降低1.03（95%置信区间：0.10，1.96）ms，静息DC降低0.67（95%置信区间：-0.14，1.49）ms。
长期金属颗粒暴露会降低心脏的加速和减速能力。
