Marino Júnior R, Gronich G
Division of Functional Neurosurgery, University of São Paulo Medical School, Brasil.
Arq Neuropsiquiatr. 1989 Sep;47(3):320-5. doi: 10.1590/s0004-282x1989000300012.
Corpus callosum stimulation produced by chronically implanted electrodes, placed either by craniotomy or stereotactically, failed to control refractory generalized epilepsy in humans and also in experimentally produced penicillin epilepsy in cats. However, the patients that suffered craniotomy, frontal lobe retraction or pneumoencephalograms, without callosal section, showed remarkable improvement of their seizure condition due to these unspecific manipulation effects. Stereotactic anterior callosotomy emerged as a sequel of these functional neurosurgical findings, and as an alternative procedure to preclude undesirable neuropsychological and neurological side effects of split brain syndrome and of brain retraction, associated to conventional callosotomy. Ten patients with various disabling convulsive disorders have undergone this new operation, which showed to be less traumatic and better tolerated than open callosotomy.
通过开颅手术或立体定向放置的长期植入电极所产生的胼胝体刺激，未能控制人类的难治性全身性癫痫，在实验性诱发的猫青霉素癫痫中也未能奏效。然而，那些接受了开颅手术、额叶牵拉或气脑造影但未进行胼胝体切断的患者，由于这些非特异性的操作效果，其癫痫状况有了显著改善。立体定向前胼胝体切开术作为这些功能性神经外科研究结果的后续发展，成为一种替代手术，以避免与传统胼胝体切开术相关的裂脑综合征和脑牵拉所带来的不良神经心理学和神经学副作用。十名患有各种致残性惊厥性障碍的患者接受了这种新手术，结果显示它比开放性胼胝体切开术创伤更小，耐受性更好。
