Frade Amanda Farage, Laugier Laurie, Ferreira Ludmila Rodrigues Pinto, Baron Monique Andrade, Benvenuti Luiz Alberto, Teixeira Priscila Camillo, Navarro Isabela Cunha, Cabantous Sandrine, Ferreira Frederico Moraes, da Silva Cândido Darlan, Gaiotto Fabio Antônio, Bacal Fernando, Pomerantzeff Pablo, Santos Ronaldo Honorato Barros, Kalil Jorge, Cunha-Neto Edecio, Chevillard Christophe
Aix-Marseille Université, INSERM, GIMP UMR_S906, 13385, France Laboratory of Immunology Division of Clinical Immunology and Allergy, School of Medicine, University of São Paulo Institute for Investigation in Immunology, National Institutes of Science and Technology.
Aix-Marseille Université, INSERM, GIMP UMR_S906, 13385, France.
J Infect Dis. 2016 Jul 1;214(1):161-5. doi: 10.1093/infdis/jiw095. Epub 2016 Mar 6.
Long noncoding RNAs (lncRNAs) modulate gene expression at the epigenetic, transcriptional, and posttranscriptional levels. Dysregulation of the lncRNA known as myocardial infarction-associated transcript (MIAT) has been associated with myocardial infarction. Chagas disease causes a severe inflammatory dilated chronic cardiomyopathy (CCC). We investigated the role of MIAT in CCC. A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls. These results were confirmed in a mouse model. Results suggest that MIAT is a specific biomarker of CCC.
长链非编码RNA（lncRNAs）在表观遗传、转录和转录后水平调节基因表达。一种名为心肌梗死相关转录本（MIAT）的lncRNA失调与心肌梗死有关。恰加斯病会引发严重的炎症性扩张型慢性心肌病（CCC）。我们研究了MIAT在CCC中的作用。对心脏活检标本以及福尔马林固定、石蜡包埋样本的全转录组分析显示，与非炎症性扩张型心肌病患者和对照组相比，MIAT在CCC患者中过表达。这些结果在小鼠模型中得到了证实。结果表明，MIAT是CCC的一种特异性生物标志物。
