Hou Gonglin, Tang Mingming, Yan Linlin, Wang Mingming
Department of psychology, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Acta Neuropsychiatr. 2012 Jun;24(3):160-5. doi: 10.1111/j.1601-5215.2011.00599.x.
To understand the underlying mechanism of gastric symptoms in patients with depressive disorder.
This study tested in the rat depression model evoked with chronic mild stress whether the microstructure gastric mucosa is injured using scanning electronic microscopy and transmission electronic microscopy (TEM). In addition, the expression of heat shock protein 70 (HSP70) and fibroblast growth factor 2 (FGF2) proteins in the gastric mucosa were measured by Western blotting.
We found that the gastric epithelial cells were ruptured and the gastric pits were widened in rats with depression. The amount of mucous granules was also reduced in the surface mucous cells. Moreover, parietal cells became active, and the secretory canaliculi were magnified. Expression of HSP70 and FGF2 was reduced in the gastric mucosa.
These findings suggested that gastric symptoms in rats with depressive-like behaviour were caused by the injury of the gastric mucosa, AQ1 and HSP70 and FGF2 may be key molecules in the pathogenesis.
了解抑郁症患者胃部症状的潜在机制。
本研究利用扫描电子显微镜和透射电子显微镜（TEM），在慢性轻度应激诱发的大鼠抑郁模型中检测胃黏膜微观结构是否受损。此外，通过蛋白质免疫印迹法检测胃黏膜中热休克蛋白70（HSP70）和成纤维细胞生长因子2（FGF2）蛋白的表达。
我们发现，抑郁大鼠的胃上皮细胞破裂，胃小凹增宽。表面黏液细胞中的黏液颗粒数量也减少。此外，壁细胞变得活跃，分泌小管扩大。胃黏膜中HSP70和FGF2的表达降低。
这些发现表明，具有抑郁样行为的大鼠的胃部症状是由胃黏膜损伤引起的，AQ1、HSP70和FGF2可能是发病机制中的关键分子。
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