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HIF repressors under chronic hypoxia.

作者信息

Luo Weibo, Wang Yingfei

机构信息

Departments of Pathology and Pharmacology, UT Southwestern Medical Center, Dallas, TX 75390, USA.

出版信息

Aging (Albany NY). 2016 Mar;8(3):418-9. doi: 10.18632/aging.100922.

Abstract
摘要

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Tristetraprolin regulates the stability of HIF-1alpha mRNA during prolonged hypoxia.
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Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha.
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